金山科研平台，产品价格货期咨询微信：jinshanbio Source:E. coli-derived, Ala28-Asn100 Accession #:P10889 N-terminal Sequence Analysis:Ala28 Purity:>97%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:8 kDa Activity:Measured by its ability to induce myeloperoxidase release from cytochalasin B-treated human neutrophils. Schröder, J.M. etal. (1987) J.Immunol. 139:3474.The ED₅₀ for this effect is typically 0.15-0.3µg/mL.Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CXCR2.The ED₅₀ for this effect is typically 0.1-0.5ng/mL. Molecule Information: CXCL2/GRO beta/MIP-2/CINC-3 Aliases: CINC-3; GRO beta; MGSA-beta; MIP-2 Entrez Gene IDs: 2920 (Human); 20310 (Mouse); 114105 (Rat) Background: CXCL1, 2, 3

Cotton rat growth-regulated protein (GRO) is a member of the ELR+ CXC subfamily of chemokines. The cotton rat GRO cDNA encodes a 100 amino acid (aa) precursor protein with a 27 aa putative signal peptide and a 73 aa mature protein.

The predicted amino acid sequence of the mouse KC gene product indicates KC is a member of the CXC subfamily of chemokines. The protein sequence of mouse KC shows approximately 63% identity to that of mouse MIP-2. In addition, the protein sequence of KC is approximately 60% identical to the human GROs. It has been suggested that mouse KC and MIP-2 are the homologs of the human GROs and rat CINCs. KC mRNA is expressed in macrophages, endothelial cells, and fibroblasts.

The rat chemokines CINC (cytokine-induced neutrophil chemoattractant)-1, CINC-2 alpha, CINC-2 beta and CINC-3 constitute a group of rat CXC chemokines that show significant sequence similarity to human GROs and mouse MIP-2 and KC.