金山科研平台，产品价格货期咨询微信：jinshanbio Source:E. coli-derived, Gly23-Lys67 Accession #:P81534 N-terminal Sequence Analysis:Gly23 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:5.2 kDa Activity:Measured by its anti-microbial activity against E. coli. Ganz,T. etal. (2003) Nat. Rev. Immunol. 3:710.The ED₅₀ for this effect is typically 7.5-30 µg/mL.Measured by its ability to promote internalization of cell surface CXCR4 on Jurkat human acute T cell leukemia cells. Quinones-Mateu, M.E. et al. (2003) AIDS 17:F39.As determined by flow cytometric analysis, the effect is typically a 2‑3fold reduction in fluorescence intensity of Jurkat cells stained with a CXCR4 antibody (Catalog# FAB170P) following a 2hour pre-treatment with 10 µg/mL human beta -Defensin 3 compared to untreated cells.Optimal dilutions should be determined by each laboratory for each application. Formulation:Lyophilized from a 0.2 µm filtered solution in HCl.See Certificate of Analysis for details. Molecule Information: beta-Defensin 3 Aliases: BD14; BD3; DEFB103A; DEFB103B; DEFB3; HBD-3 Entrez Gene IDs: 55894 (Human) Background: beta-Defensin 3 Defensins are members of a family of microbicidal and cytotoxic peptides produced by neutrophils. They are classified into alpha-, beta-, and theta-defensins based on their sizes and intramolecular disulfide bond patterns. They are produced in a tissue-restricted manner in response to microbial products or pro- inflammatory cytokines. beta-Defensin 2 is induced in skin, airway epithelial cells, and keratinocytes, while beta-Defensin 3 is expressed primarily in salivary gland, pancreas, and gonadal structures.