货号：07-497

品牌：Merck Millipore

规格：

目录价：￥4505.00

市场价格：￥3829.25

会员价格：￥3604.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-p47-phox Antibody | 07-497 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes p47-phox, Mr ~47 kDa. View All» Molecular Weight: 47 kDa View All» Immunogen: GST fusion protein corresponding to full length human p47-phox. View All» Isotype: IgG View All» Background Information: NADPH Oxidase (nicotinamide adenine dinucleotide phosphate-oxidase) complex is composed of p47 phox (cytosolic component bound to PKC that localizes to p22), p67 phox (cytosolic component that interacts with activated Rac to dock on the glycoprotein p91 subunit (gp91) of membrane bound cytochrome b), Rac2 (Rho family of GTPases), b558 (a cytochrome b transmembrane protein dimer made up of gp91 phox/p22 phox). The activated complex is responsible for the respiratory burst in neutrophils by the multiple phosphorylations of p47 phox by PKC. View All» Species Reactivity:

• Human

• Rat

• Bovine
  View All» Species Reactivity Note: Human and rat. Reported cross-reactivity with bovine. View All» Application Notes: Electron Microscopy: An independent laboratory reported detection of p47-phox in human neutrophils. (Wienties, F.B., 1997) View All» Control: HL-60 cell lysate. View All» Quality Assurance: Routinely evaluated by western blot in in RIPA lysates from HL-60 cells.Western Blot Analysis: A 1:500-1:1000 dilution of this lot detected p47-phox in RIPA lysates from HL-60 cells. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal antiserum IgG in buffer containing 0.05% sodium azide and 30% glycerol. Liquid at -20°C. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variabillity in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P46527 View All» Entrez Gene Number: NP_000256 View All» Gene Symbol:
  • CDKN1B

  • P27KIP1

  • MEN1B

  • MEN4

  • KIP1

  • p27Kip1

  • CDKN4
    View All» Alternate Names:
    • Cyclin-dependent kinase inhibitor p27

    • cyclin-dependent kinase inhibitor 1B

    • cyclin-dependent kinase inhibitor 1B (p27, Kip1)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry (Paraffin)

      • Western Blotting
        View All» Entrez Gene Summary: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. View All» UniProt Summary: FUNCTION:SwissProt: P46527 # Involved in G1 arrest. May mediate TGF beta-induced G1 arrest. Binds to and inhibits complexes formed by cyclin E-CDK2, cyclin A-CDK2, and cyclin D1-CDK4. Interaction with nucleoporin NUP50 is required for nuclear import and for degradation of phosphorylated p27Kip1 after nuclear import (By similarity).SIZE: 198 amino acids; 22073 Da SUBUNIT: Interacts with NUP50 and with UHMK1. Interacts with COPS5 subunit of COP9 signalosome complex, leading to its subsequent degradation (By similarity). Interacts with SPDYA and is found in a complex with both SPDYA and CDK2.SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Note=Nuclear and cytoplasmic in quiescent cells. Upon cell cycle progression, mostly cytoplasmic (By similarity).TISSUE SPECIFICITY: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.DOMAIN: SwissProt: P46527 A peptide sequence containing only AA 28-79 retains substantial KIP1 cyclin A/CDK2 inhibitory activity.PTM: Phosphorylation on Ser-10 leads to nuclear export to the cytoplasm and promotes cell cycle progression (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.DISEASE: SwissProt: P46527 # Defects in CDKN1B are the cause of multiple endocrine neoplasia type 4 (MEN4) [MIM:610755]. Multiple endocrine neoplasia (MEN) syndromes are inherited cancer syndromes of the thyroid. MEN4 is a MEN-like syndrome with a phenotypic overlap of both MEN1 and MEN2.SIMILARITY: Belongs to the CDI family. View All» Brand Family: Upstate View All» Product Name: Anti-p47-phox Antibody | 07-497 View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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