货号：07-474

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-p38γ/SAPK3 Antibody | 07-474 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: p38 gamma isoform/SAPK3 View All» Molecular Weight: 43kDa View All» Immunogen: GST-fusion protein corresponding to full-length human Anti-p38γ/SAPK3. View All» Isotype: IgG View All» Species Reactivity: Human View All» Quality Assurance: Routinely evaluated by immunoblot in a RIPA lysate from HeLa cells View All» Purification Method: Protein A chromatography View All» Presentation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P53778 View All» Entrez Gene Number: NM_002969 View All» Gene Symbol:

• MAPK12

• ERK5

• P38GAMMA

• p38gamma

• ERK3

• ERK6

• ERK-6

• PRKM12

• SAPK3

• SAPK-3
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. View All» UniProt Summary: FUNCTION: SwissProt: P53778 # Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. Plays a role in myoblast differentiation and also in the down- regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.COFACTOR: Binds 2 magnesium ions.SIZE: 367 amino acids; 41940 Da SUBUNIT: Monomer. Interacts with the PDZ domain of the syntrophin SNTA1. Interacts with SH3BP5.SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion. Note=Mitochondrial when associated with SH3BP5.TISSUE SPECIFICITY: Highly expressed in skeletal muscle and heart.DOMAIN: SwissProt: P53778 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.PTM: Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme (By similarity).SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Product Name: Anti-p38γ/SAPK3 Antibody | 07-474 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Rabbit View All»
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