货号：07-432

品牌：Merck Millipore

规格：100Ug

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-K+/Cl- Cotransporter (KCC2) Antibody | 07-432 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes rat K+/Cl- Cotransporter (KCC2), Mr ~140 kDa. An unknown band >200 kDa was also detected. View All» Molecular Weight: 140 kDa View All» Immunogen: N-terminal His-tag fusion protein corresponding to residues 932-1043 of rat K+/Cl- Cotransporter (KCC2). View All» Isotype: IgG View All» Background Information: KCC2 is a member of the cation-chloride cotransporter gene family. It acts as a K-Cl cotransporters. KCCs normally lower intracellular chloride concentrations below the electrochemical equilibrium potential and depending on the chemical concentration gradients of potassium and chloride, KCC2 can operate as a net efflux or influx pathway. It is proposed to act as the main chloride extruder to promote fast hyperpolarizing postsynaptic inhibition in the brain. KCC2 is expressed at high levels in neurons throughout the nervous system and immunofluorescence shows that the protein is localized at inhibitory synapses of the spinal cord. Studies in mice have shown that KCC2 reduces GABA's inhibitory signaling, resulting in motor defects, epilepsy, and anxiety-like behavior. View All» Species Reactivity:

• Rat

• Canine
  View All» Species Reactivity Note: Rat and dog. Wide range of species cross-reactivity expected due to sequence homology. View All» Application Notes: Immunocytochemistry: This antibody has been reported by an independent laboratory to detect K+/Cl- Cotransporter (KCC2) in Madin Darby Canine Kidney (MDCK) cells at 1:200 dilution. View All» Control: Rat brain membrane preparation. View All» Quality Assurance: Routinely evaluated by western blot in rat brain membrane preperations.Western Blot Analysis: 1.0 µg/mL of this lot detected K+/Cl- Cotransporter (KCC2) in rat brain membrane preparations. View All» Purification Method: Protein A purfied View All» Presentation: Purified rabbit polyclonal IgG in buffer containing 0.014 M Phosphate buffer, pH 7.6, 0.175 M NaCl, 0.07% sodium azide and 30% glycerol. Liquid at -20°C. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variabillity in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: Q9H2X9 View All» Entrez Gene Number: NP_065759 View All» Gene Symbol:
  • SLC12A5

  • KIAA1176

  • hKCC2

  • KCC2
    View All» Alternate Names:
    • Electroneutral potassium-chloride cotransporter 2

    • Erythroid K-Cl cotransporter 2

    • Neuronal K-Cl cotransporter

    • electroneural potassium-chloride cotransporter 2

    • solute carrier family 12 (potassium-chloride transporter), member 5
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunocytochemistry

      • Western Blotting
        View All» Entrez Gene Summary: K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. View All» UniProt Summary: FUNCTION: SwissProt: Q9H2X9 # Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons.SIZE: 1139 amino acids; 126184 Da SUBUNIT: Homomultimer and heteromultimer with other K-Cl cotransporters (By similarity).SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Brain specific. Detected in neuronal cells.SIMILARITY:SwissProt: Q9H2X9 ## Belongs to the SLC12A transporter family. MISCELLANEOUS: Inhibited by furosemide and bumetanide. View All» Brand Family: Upstate View All» Product Name: Anti-K+/Cl- Cotransporter (KCC2) Antibody | 07-432 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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        © Merck Millipore代理07-432 Anti-K+/Cl- Cotransporter (KCC2) Antibody;抗-K+/Cl-共转运蛋白（KCC2）抗体store at -20℃，产品报价联系微信jinshanbio