货号：07-403

品牌：Merck Millipore

规格：

目录价：￥4657.00

市场价格：￥3958.45

会员价格：￥3725.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cu/Zn-SOD Antibody | 07-403 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes Cu/Zn-SOD. View All» Molecular Weight: 16 kDa View All» Immunogen: Recombinant protein corresponding to full-length human Cu/Zn-SOD (superoxide dismutase) plus an n-terminal methionine View All» Isotype: IgG View All» Species Reactivity:

• Human

• Rat
  View All» Control: Positive Control Included: Non-Stim A431 Cell Lysate (12-301) View All» Quality Assurance: routinely evaluated by immunoblot in RIPA lysates from A431 cells View All» Purification Method: Unpurified View All» Presentation: Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative. View All» Storage Conditions: Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P00441 View All» Entrez Gene Number: NM_000454 View All» Gene Symbol:
  • SOD1

  • IPOA

  • SOD

  • ALS

  • homodimer

  • ALS1

  • Cu-Zn
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P00441 # Destroys radicals which are normally produced within the cells and which are toxic to biological systems.COFACTOR: Binds 1 copper ion per subunit. & Binds 1 zinc ion per subunit.SIZE: 154 amino acids; 15936 Da SUBUNIT: Homodimer. The pathogenics variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 interact with RNF19A, whereas wild-type protein does not.SUBCELLULAR LOCATION: Cytoplasm.PTM: Unlike wild-type protein, the pathogenics variants ALS1 Arg- 38, Arg-47, Arg-86 and Ala-94 are polyubiquitinated by RNF19A; which leads to their proteasomal degradation.DISEASE: SwissProt: P00441 # Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:105400]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.SIMILARITY: SwissProt: P00441 ## Belongs to the Cu-Zn superoxide dismutase family.MISCELLANEOUS: Zinc binding promotes dimerization. View All» Brand Family: Upstate View All» Product Name: Anti-Cu/Zn-SOD Antibody | 07-403 View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 250 μL View All» Format: Serum View All» Host: Rabbit View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://16ao.com/thread-135626.htm
    © Merck Millipore代理07-403 Anti-Cu/Zn SOD (rabbit antiserum)，产品报价联系微信jinshanbio