货号：07-337

品牌：Merck Millipore

规格：200Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SOS1 Antibody, CT | 07-337 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: SOS1 View All» Molecular Weight: 175 kDa View All» Immunogen: peptide corresponding to amino acids 1243-1258 (KKSDHGNAFFPNSPSP) of murine Son of Sevenless Homolog 1 Protein (SOS 1) View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse
  View All» Quality Assurance: routinely evaluated by immunoblot on 3T3/A31, A431 cell lysates, or HeLa nuclear extracts View All» Purification Method: Protein A chromatography View All» Presentation: Protein A purified Rabbit Ig in 0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH 7.4. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q07889 View All» Entrez Gene Number: NM_005633 View All» Gene Symbol:
  • SOS1

  • NS4

  • SOS-1

  • GF1

  • HGF

  • GGF1

  • GINGF
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. View All» UniProt Summary: FUNCTION: SwissProt: Q07889 # Promotes the exchange of Ras-bound GDP by GTP.SIZE: 1333 amino acids; 152464 Da SUBUNIT: Interacts with GRB2. Interacts with phosphorylated LAT2.TISSUE SPECIFICITY: Expressed in gingival tissues.DISEASE: SwissProt: Q07889 # Defects in SOS1 are the cause of gingival fibromatosis 1 (GGF1) [MIM:135300]; also designated GINGF1. Gingival fibromatosis is a rare overgrowth condition characterized by a benign, slowly progressive, nonhemorrhagic, fibrous enlargement of maxillary and mandibular keratinized gingiva. GGF1 is usually transmitted as an autosomal dominant trait, although sporadic cases are common. & Defects in SOS1 are the cause of Noonan syndrome type 4 (NS4) [MIM:610733]. NS4 is an autosomal dominant disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incidence of 1 in 1000-2500 live births. Rarely, NS4 is associated with juvenile myelomonocytic leukemia (JMML). SOS1 mutations engender a high prevalence of pulmonary valve disease; atrial septal defects are less common.SIMILARITY: SwissProt: Q07889 ## Contains 1 DH (DBL-homology) domain. & Contains 1 N-terminal Ras-GEF domain. & Contains 1 PH domain. & Contains 1 Ras-GEF domain. View All» Brand Family: Upstate View All» Product Name: Anti-SOS1 Antibody, CT | 07-337 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Rabbit View All»
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