货号：07-327

品牌：Merck Millipore

规格：100UL

目录价：￥6742.00

市场价格：￥5730.70

会员价格：￥5393.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-acetyl-Histone H4 (Lys5) Antibody | 07-327 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the N-terminus of Histone H4 acetylated at Lys5. View All» Molecular Weight: ~13 kDa observed View All» Epitope: N-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the N-terminus of Histone H4 acetylated at Lys5. View All» Modifications: Acetylation View All» Background Information: Histone H4 is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N terminal tail H4 is involved with the structure of the nucleosomes of the 'beads on a string' structure. Acetylation of histone H4 occurs at several different lysine positions in the histone tail and is performed by a family of enzymes known as Histone Acetyl Transferases (HATs). View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human based on 100% sequence homology. This antibody is expected to demonstrate broad species cross-reactivity. View All» Application Notes: Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected acetyl-Histone H4 in HeLa and A431 cells.Dot Blot Specificity Analysis: A representative lot detected acetyl-histone H4 (Lys5) peptides, but not unacetylated-histone H4 (Lys4) peptides or other peptides corresponding to modified histones.Chromatin Immunoprecipitation Analysis: 5 µL from a representative lot immunoprecipitated acetyl-Histone H4 in HeLa S3 chromatin. View All» Control: HeLa acid extract View All» Quality Assurance: Evaluated by Western Blot in HeLa acid extract.Western Blot Analysis: A 1:2,000 dilution of this antibody detected acetyl-Histone H4 in 10 µg of HeLa acid extract. View All» Purification Method: Purified by immunodepletion View All» Presentation: Immunodepleted rabbit serum with 0.05% soduim azide and 30% glycerol. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P62805 View All» Entrez Gene Number: NP_001029249 View All» Gene Symbol:

• HIST1H4A

• H4/A

• H4FA

• HIST1H4B

• H4/I

• H4FI

• HIST1H4C

• H4/G

• H4FG

• HIST1H4D

• H4/B

• H4FB

• HIST1H4E

• H4/J

• H4FJ

• HIST1H4F

• H4/C

• H4FC

• HIST1H4H

• H4/H

• H4FH

• HIST1H4I

• H4/M

• H4FM

• HIST1H4J

• H4/E

• H4FE

• HIST1H4K

• H4/D

• H4FD

• HIST1H4L

• H4/K

• H4FK

• HIST1H4L

• H4/K

• H4FK

• HIST1H4L

• H4/K

• H4FK

• HIST2H4A

• H4/N

• H4F2

• H4FN

• HIST2H4

• HIST2H4B

• H4/O

• H4FO

• HIST4H4
  View All» Alternate Names: Histone H4 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Dot Blot

  • Immunocytochemistry

  • ChIP-seq
    View All» Entrez Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. View All» UniProt Summary: FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.SUBUNIT STRUCTURE: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.SUBCELLULAR LOCATION: Nucleus. Chromosome. View All» Product Name: Anti-acetyl-Histone H4 (Lys5) View All» Concentration: N/A mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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