货号：07-282

品牌：Merck Millipore

规格：

目录价：￥3522.00

市场价格：￥2993.70

会员价格：￥2817.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Rb2 (p130) View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Rb2 View All» Molecular Weight: 130kDa View All» Immunogen: peptide corresponding to amino acids 1120-1139, (ENHSALLRRLQDVANDRGSH) of human Rb2 (p130) View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from T98G cells View All» Purification Method: Antiserum View All» Presentation: antiserum containing 0.01% sodium azide View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: Q08999 View All» Entrez Gene Number: NM_005611 View All» Gene Symbol:
  • RBL2

  • Rb2

  • P130

  • PRB2

  • RB2

  • p130

  • FLJ26459

  • RBR-2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: Q08999 # Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.SIZE: 1139 amino acids; 128367 Da SUBUNIT: Interacts with AATF. Interacts with SUV420H1 and SUV420H2 (By similarity). Interacts with RINT1.SUBCELLULAR LOCATION: Nucleus.PTM: During G0 and early G1 phase of the cell cycle, phosphorylated on Ser-639 and on 5 sites within the domain B. Phosphorylation on Ser-672 in G1 leads to its ubiquitin-dependent proteolysis.SIMILARITY: SwissProt: Q08999 ## Belongs to the retinoblastoma protein (RB) family.MISCELLANEOUS: G0-restricted expression. View All» Brand Family: Upstate View All» Product Name: Anti-Rb2 (p130) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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