货号：07-1575

品牌：Merck Millipore

规格：

目录价：￥4934.00

市场价格：￥4193.90

会员价格：￥3947.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho HDAC1 (Ser421/Ser423) Antibody | 07-1575 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes HDAC1 phosphorylated Ser421/Ser423. View All» Molecular Weight: ~62 kDa observed View All» Epitope: Phosphorylated Ser421/Ser423 View All» Immunogen: Linear peptide corresponding to human HDAC1 phosphorylated Ser421/Ser423. View All» Modifications:

• Phosphorylation

• Phosphorylation
  View All» Background Information: Histone deacetylation acts a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylase (HDAC) and histone acetyltransferase (HAT) catalyze this reversible histone acetylation that governs the dynamics of transcriptionally active genes. HDAC1 and HDAC2, belong to class 1 HDAC, contain most of HDAC activity in mammalian cells. HDAC1/2 are core components of multi-protein core repressor complexes containing HDAC1, HDAC2, Rbbp4 and Rbbp7. Phosphorylation of HDAC1/2 enhances enzymatic activity and the association of other proteins. Phosphorylated HDAC1/2 is recruited to a variety of promoters by transcription factors including p53, Rb, YY1, NF-kB, Sp1 and Sp3. Specific phosphorylation of HDAC1 on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. May recognize Mouse and Rat due to 92% sequence homology with human immunogen. View All» Control: Nocodazol treated and untreated HeLa acid extract View All» Quality Assurance: Evaluated by Western Blot in Nocodazol treated and untreated HeLa acid extract.Western Blot Analysis: 1:1,000 dilution of this antibody detected HDAC1 on 10 µg of Nocodazol treated and untreated HeLa acid extract. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q13547 View All» Entrez Gene Number: NP_004955 View All» Gene Symbol:
  • HDAC1

  • RPD3L1
    View All» Alternate Names:
    • Histone deacetylase 1

    • HD1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.SUBUNIT STRUCTURE: Part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associates with MTA2, MBD2, MBD3, MTA1L1, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylation (NuRD) complex, or with SIN3, SAP18 and SAP30 to form the SIN3 HDAC complex. Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Associates with the 9-1-1 complex; interacts with HUS1. Found in a complex with DNMT3A and HDAC7. Interacts with BAZ2A/TIP5, BCOR, BRMS1L, DAXX, DNMT1, EP300, HCFC1, NFE4, PCAF, PHB2, MIER1, KDM4A, MINT, NRIP1, PRDM6, RERE, SETDB1, SMYD2, SUV39H1, TGIF, TGIF2, UHRF1, UHRF2 and ZNF541. Interacts with the non-histone region of H2AFY. Interacts with HDAC9. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Interacts with BANP, CBFA2T3 and KDM5B. Interacts with SAP30L. Interacts with E4F1. Interacts with KFL1 By similarity. Interacts with SV40 large T antigen. Interacts with CHFR, PRDM16, SP1, SP3 and SMAD3. Interacts with RB1 and SMARCA4/BRG1. Interacts with TRAF6. Interacts with TSHZ3 (via N-terminus); the interaction is direct. Found in a trimeric complex with APBB1 and TSHZ3; the interaction between HDAC1 and APBB1 is mediated by TSHZ3. Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1. Interacts with NR4A2/NURR1 and BRMS1 (By similarity). SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICTY: Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain.PTM: Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1. Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes.Ubiquitinated by CHFR, leading to its degradation by the proteasome (By similarity).SEQUENCE SIMILARITIES: Belongs to the histone deacetylase family. HD type 1 subfamily. View All» Product Name: Anti-phospho HDAC1 (Ser421/Ser423) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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