货号：07-1534

品牌：Merck Millipore

规格：

目录价：￥4633.00

市场价格：￥3938.05

会员价格：￥3706.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-JMJD3 Antibody (C-terminus) | 07-1534 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Recognizes the C-terminal region of murine JMJD3. Additional non-specific, lower molecular weight bands are detected in some lysates. View All» Molecular Weight: ~180 kDa View All» Epitope: C-terminus View All» Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of murine JMJD3. View All» Background Information: JMJD3 (Jumonji domain-containing protein 3) is part of the family of novel JmjC domain-containing histone demethylation (JHDM) enzymes. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. JMJD3 specifically demethylates Lys27 on histone H3, demethylating both the trimethylated and dimethylated form. JMJD3 plays a role in the regulation of posterior development by regulating HOX gene expression. It is also involved in the inflammatory response by regulating gene expression and macrophage differentiation View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human and mouse. Not tested in other species. View All» Application Notes: Western Blot Analysis:This antibody is reported by an outside laboratory to be suitable for Western blottingELISA:This antibody is reported by an outside laboratory to be suitable for ELISA View All» Control: HeLa cells, NIH/3T3 cells View All» Quality Assurance: Immunocytochemisty: Recognizes JMJD3 in NIH 3T3 and A431 cells by cytochemistry. View All» Purification Method: Protein G chromatography View All» Presentation: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial to pellet the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: O15054 View All» Entrez Gene Number: NP_001017426 View All» Gene Symbol:
  • EC 1.14.11

  • KDM6B

  • KIAA0346
    View All» Alternate Names:
    • JMJD

    • JmjC domain-containing protein 3

    • Jumonji domain-containing protein 3

    • Lysine demethylase 6B

    • jumonji domain containing 3

    • jumonji domain containing 3, histone lysine demethylase
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunocytochemistry

      • ELISA

      • Western Blotting
        View All» UniProt Summary: FUNCTION: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Ref.5 Ref.6Cofactor Ascorbate By similarity.Fe(2+). Ref.5SUBUNIT STRUCTURE: Interacts with TLE1 By similarity. Component of the MLL4 complex, at least composed of MLL4, ASH2L, RBBP5, WDR5, and JMJD3.SUBCELLULAR lOCATION: NucleusProbable. INDUCTION: By 12-O-tetradecanoylphorbol-13-acetate (TPA) in myeloid leukemia cells. Ref.4SIMILARITY: Belongs to the UTX family.Contains 1 JmjC domain. View All» Product Name: Anti-JMJD3 Antibody (C-terminus) (07-1534) View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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