货号：07-1531

品牌：Merck Millipore

规格：200Y56

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-PFKFB2 (Ser466) Antibody | 07-1531 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes PFKFB2 phosphorylated at Ser466. View All» Molecular Weight: ~58 kDa observed. Uniprot describes two isoforms at 54 kDa (isoform 1) and 58 kDa (isoform 2). View All» Epitope: Phosphorylated Ser466 View All» Immunogen: KLH-conjugated linear peptide corresponding to human PFKFB2 phosphorylated at (Ser466). View All» Modifications: Phosphorylation View All» Background Information: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2) is an enzyme involved in both the synthesis and degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart (a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle) to regulate glycolysis and gluconeogensis. View All» Species Reactivity:

• Human

• Rat

• Mouse

• Bovine

• Xenopus

• Primate
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Rat, Mouse, Bovine, Xenopus, and Primate based on 100% sequence homology. View All» Application Notes: Peptide Inihibition Analysis: A 1:500 dilution from a representative lot blocked PFKFB2 in PANC-1 cell lysate. View All» Control: Untreated and insulin-treated HEK293 cell lysates View All» Quality Assurance: Evaluated by Western Blot in Insulin untreated and treated Hek293 cell lysates.Western Blot Analysis: A 1:500 dilution of this antibody detected PFKFB2 in 10 µg of untreated and insulin-treated HEK293 cell lysates. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O60825 View All» Entrez Gene Number: NP_006203 View All» Gene Symbol: PFKFB2 View All» Alternate Names:
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

  • 6PF-2-K/Fru-2,6-P2ase 2

  • PFK/FBPase 2

  • 6PF-2-K/Fru-2,6-P2ase heart-type isozyme

  • 6-phosphofructo-2-kinase

  • Fructose-2,6-bisphosphatase
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Peptide Inhibition Assay
      View All» Entrez Gene Summary: The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. View All» UniProt Summary: FUNCTION: Synthesis and degradation of fructose 2,6-bisphosphate.CATALYTIC ACTIVITY: Beta-D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.ENZYME REGULATION: Phosphorylation results in the activation of the kinase activity.SUBUNIT STRUCTURE: Homodimer (By similarity).TISSUE SPECIFICITY: Heart.SEQUENCE SIMILARITIES: In the C-terminal section; belongs to the phosphoglycerate mutase family. View All» Product Name: Anti-phospho-PFKFB2 (Ser466) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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