货号：07-1527

品牌：Merck Millipore

规格：EA

目录价：￥3228.00

市场价格：￥2743.80

会员价格：￥2582.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TFIIF-alpha Antibody | 07-1527 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes GTF2F1 at the C-terminus. View All» Molecular Weight: ~74 kDa observed View All» Epitope: C-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to human TFIIF-alpha at the C-terminus. View All» Background Information: TFIIF, a general transcription initiation factor, is a heterodimer composed of 74 kDa, GTF2F1 (Rap74), and a 30 kDa (GTF2F2) subunits. TFIIF is involved in transcription initiation and elongation, and the CTD of GTF2F1 binds to the RNA polymerase II enzyme, the general transcription factor TFIIB, and a CTD phosphate, FCP1. Studies point to TFIIF involvement in both early and late transcriptional stages. Data also suggest that GTF2F1 is involved in the in the recycling of the RNA Polymerase II via FCP1's CTD-specific phosphatase activity. View All» Species Reactivity:

• Human

• Bovine

• Pig

• Chimpanzee
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Bovine, Porcine, Orangutan, and Chimpanzee based on 100% sequence homology. View All» Application Notes: Immunoprecipitation Analysis: 10 µg of this antibody immunoprecipitated TFIIF-alpha from K562 RIPA lysate. View All» Control: K562 cell lysate View All» Quality Assurance: Evaluated by Western Blot in K562 cell lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected TFIIF-alpha on 10 µg of K562 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P35269 View All» Entrez Gene Number: NP_002087 View All» Gene Symbol:
  • GTF2F1

  • RAP74
    View All» Alternate Names:
    • General transcription factor IIF subunit 1

    • General transcription factor IIF 74 kDa subunit

    • Transcription initiation factor IIF subunit alpha

    • TFIIF-alpha

    • Transcription initiation factor RAP74
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation
        View All» UniProt Summary: FUNCTION: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. SUBUNIT STRUCTURE: Heterodimer of an alpha and a beta subunit. Interacts with GTF2F2 and CTDP1. Interacts with TAF6/TAFII80. SUBCELLULAR LOCATION: Nucleus. INDUCTION: Up-regulated in response to enterovirus 71 (EV71) infection. PTM: Phosphorylated on Ser and other residues by TAF1 and casein kinase II-like kinases. SEQUENCE SIMILARITIES: Belongs to the TFIIF alpha subunit family.CAUTION: Was reported (Ref.9) to have a protein kinase activity and to autophosphorylates on Ser-385 and Thr-389. View All» Product Name: Anti-TFIIF-alpha View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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