货号：07-1514

品牌：Merck Millipore

规格：

目录价：￥3943.00

市场价格：￥3351.55

会员价格：￥3154.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-WAVE2 (Ser351) Antibody | 07-1514 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes WAVE2 phosphorylated at Ser351. View All» Molecular Weight: ~84 kDa observed. On WB, band runs at ~84 kDa (Yan, C., et al. (2003). EMBO. 22:3602-3612), despite having a calculated MW of ~54 kDa. View All» Epitope: Phosphorylated Ser351 View All» Immunogen: KLH-conjugated linear peptide corresponding to human WAVE2 phosphorylated at Ser351. View All» Modifications: Phosphorylation View All» Background Information: Wiskott-Aldrich Syndrome Protein (WASP)-family Protein Member 2 (known as WAVE2) has a very wide distribution with strong expression in peripheral blood leukocytes. WAVE2 is involved in signaling RTKs and small GTPases. In general WAVE family of proteins have a general function for regulating the actin cytoskeleton in various tissues. View All» Species Reactivity:

• Monkey

• Human

• Rat

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Monkey and Human. Predicted to react with Rat and Mouse based on 100% sequence homology. View All» Application Notes: Western Blot Analysis: A representative lot was used by an independent laboratory to detecct phospho-WAVE2 (Ser351) in human mammary cells treated with EGF and 293T cells transfected with WAVE2 (Mendoza, M., et al. (2011). Molecular Cell 41:661–671). View All» Control: EGF-treated COS cells that are untreated and treated with lambda phosphatase View All» Quality Assurance: Evaluated by Western Blot in EGF-treated COS cells that are untreated and treated with lambda phosphatase.Western Blot Analysis: 0.5 µg/mL of this antibody detected phospho-WAVE2 (Ser351) in 10 µg of EGF-treated COS cells that are untreated and treated with lambda phosphatase. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9Y6W5 View All» Entrez Gene Number: NP_008921 View All» Gene Symbol:
  • WASF2

  • WAVE2
    View All» Alternate Names:
    • Wiskott-Aldrich syndrome protein family member 2

    • WASP family protein member 2

    • Protein WAVE-2

    • Verprolin homology domain-containing protein 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton.SUBUNIT STRUCTURE: Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with C3orf10/HSPC300. SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton (By similarity). Cell projection › lamellipodium (By similarity). Note: At the interface between the lamellipodial actin meshwork and the membrane (By similarity).TISSUE SPECIFICTY: Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle.DOMAIN: Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.SEQUENCE SIMILARITIES: Belongs to the SCAR/WAVE family.Contains 1 WH2 domain. View All» Product Name: Anti-phospho-WAVE2 (Ser351) View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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