货号：07-1512

品牌：Merck Millipore

规格：100UL

目录价：￥5359.00

市场价格：￥4555.15

会员价格：￥4287.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-WAVE2 (Ser343) Antibody | 07-1512 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes WAVE2 phosphorylated at Ser343. View All» Molecular Weight: ~75 kDa observed. An uncharacterized band appears at ~103 kDa in some lysates. View All» Epitope: Phosphorylated Ser343 View All» Immunogen: KLH-conjugated linear peptide corresponding to human WAVE2 phosphorylated at Ser343. View All» Modifications: Phosphorylation View All» Background Information: Wiskott-Aldrich Syndrome Protein (WASP)-family Protein Member 2 (known as WAVE2) is found in many cells and tissues, with strong expression in peripheral blood leukocytes. WAVE2 is involved in signaling RTKs and small GTPases. As a whole, the WAVE family of proteins have a general function for regulating the actin cytoskeleton in various tissues. View All» Species Reactivity:

• Human

• Monkey
  View All» Species Reactivity Note: Demonstrated to react with Human and Monkey. View All» Application Notes: Western Blot Analysis: A previous lot of this antibody was used to detect endogenous phospho-WAVE2 (Ser343) in COS-7 and HMECs following EGF stimulation ± pretreatment with U0126 (Mendoza, M.C., et al. (2011). Mol Cell. 41(6):661-671). View All» Control: COS-7+EGF cell lysates untreated and lambda phosphatase treated. View All» Quality Assurance: Evaluated by Western Blot in COS-7+EGF cell lysates untreated and lambda phosphatase-treated.Western Blot Analysis: A 1:500 dilution of this antibody detected phospho-WAVE2 (Ser343) in 10 µg of COS-7+EGF cell lysates untreated and lambda phosphatase treated. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9Y6W5 View All» Entrez Gene Number: NP_008921 View All» Gene Symbol:
  • WASF2

  • WAVE2
    View All» Alternate Names:
    • SCAR2

    • WASF2

    • dJ393P12.2

    • WASP family protein member 2

    • Protein WAVE-2

    • Verprolin homology domain-containing protein 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton.SUBUNIT STRUCTURE: Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with C3orf10/HSPC300.SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Note: At the interface between the lamellipodial actin meshwork and the membrane. View All» Product Name: Anti-phospho-WAVE2 (Ser343) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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