金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Glu25-Pro621 Accession #:Q99062 N-terminal Sequence Analysis:Glu25 Purity:>97%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:66.5 kDa SDS-PAGE:95-105 kDa, reducing conditions Activity:Measured by its ability to inhibit the G-CSF-induced proliferation of NFS‑60 mouse myelogenous leukemia lymphoblast cells.The ED₅₀ for this effect is typically 1 - 4 µg/mL in the presence of 0.125 ng/mL of rhG-CSF. Molecule Information: G-CSF R/CD114 Long Name: Granulocyte Colony Stimulating Factor Receptor Aliases: CD114; CSF3R; Csfgr Entrez Gene IDs: 1441 (Human); 12986 (Mouse) Background: G-CSF Receptor Human G-CSF R is 836 amino acids (aa) in length, with a 23 aa signal sequence, a 604 aa extracellular region, a 26 aa transmembrane segment, and a 183 aa cytoplasmic domain. As a result of alternative splicing, at least four isoforms of G-CSF R exist that differ in their transmembrane C-terminal region. Human and mouse G-CSF R are 64% identical at the aa level. G-CSF R is expressed in mature neutrophils, neutrophilic precursors, myeloid leukemia cells, and placenta.