货号：07-1491

品牌：Merck Millipore

规格：100UL

目录价：￥4899.00

市场价格：￥4164.15

会员价格：￥3919.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Calcineurin pan A Antibody | 07-1491 View All» Replaces: AB1695 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes both the Aα and Aβ, the major catalytic subunit gene isoforms of calcineurin in most tissues; may also react with the testis form, Aγ. This antibody has very high sensitivity and specificity, which allow detection of calcineurin in tissues where expression is low, such as lymphoid tissue. Reacts with calcineurin of all mammalian species. View All» Molecular Weight: ~58 kDa View All» Immunogen: KLH-conjugated synthetic peptide corresponding to Calcineurin. View All» Background Information: Calcineurin is a serine/threonine protein phosphatase involved in the mediation of signal tranduction in a wide variety of cellular responses. Calcineurin has been linked to Pmk1 MAP kinase and PI pathways, as well as to members of the small GTPase Rab/Ypt family and Type II myosin. Furthermore, calcineurin participates in the transduction of extracellular signals to the nucleus by dephosphorylation of members of the NFAT family of transcription factors. These linkages demonstrate calcineurin's multifunctional capabilities in the regulation of calcium signaling. View All» Species Reactivity: Mammals View All» Species Reactivity Note: Reacts with human, mouse, and rat. Predicted to react with all mammals based on 100% sequence homology. View All» Control: Mouse brain lysate View All» Quality Assurance: Evaluated by Western Blot in Mouse brain lysate.Western Blot Analysis: 1:1,000 dilution of this antibody detected Calcineurin on 10 µg of mouse brain lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 40% gylerol. Contains no preservative. View All» Storage Conditions: Store at -20°C for up to 12 months in undiluted aliquots; at this temperature the solution willremain unfrozen. View All» UniProt Number: Q08209 View All» Entrez Gene Number: NP_000935.1 View All» Gene Symbol:

• CALN

• CALNA

• CALNA1

• CCN1

• CNA

• CNA1

• EC 3.1.3.16

• PPP2B
  View All» Alternate Names:
  • CAM-PRP catalytic subunit

  • Calmodulin-dependent calcineurin A subunit alpha isoform

  • calcineurin A alpha

  • protein phosphatase 3 (formerly 2B), catalytic subunit,alpha isoform

  • protein phosphatase 3 (formerly 2B), catalytic subunit,alpha isoform (calcineurin A alpha)

  • protein phosphatase 3, catalytic subunit, alpha isoform

  • serine/threonine-protein phosphatase 2B catalytic subunitalpha isoform
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1. CATALYTIC ACTIVITY: A phosphoprotein + H2O = a protein + phosphate.COFACTOR:Binds 1 Fe3+ ion per subunit.Binds 1 zinc ion per subunit.SUBUNIT STRUCTURE: Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with TORC2/CRTC2, MYOZ1, MYOZ2 and MYOZ3. SUBCELLULAR LOCATION: Nucleus By similarity. Note: Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle By similarity.SEQUENCE SIMILARITIES: Belongs to the PPP phosphatase family. PP-2B subfamily. View All» Product Name: Anti-Calcineurin pan A Antibody | 07-1491 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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