货号：07-1490

品牌：Merck Millipore

规格：100UL

目录价：￥4322.00

市场价格：￥3673.70

会员价格：￥3457.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Calcineurin Antibody | 07-1490 View All» Replaces: 07-1490 is a recommended replacement for AB1694. View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Recognizes both the catalytic A and regulatory B subunits of calcineurin, a calcium- and calmodulin-dependent protein phosphatase. View All» Molecular Weight: 19 kDa View All» Immunogen: Purified bovine brain calcineurin. View All» Isotype: IgG View All» Background Information: Calcineurin/PP2B is a serine/threonine protein phosphatase involved in the mediation of signal tranduction in a wide variety of cellular responses. Calcineurin/PP2B has been linked to Pmk1 MAP kinase and PI pathways, as well as to members of the small GTPase Rab/Ypt family and Type II myosin. Furthermore, calcineurin participates in the transduction of extracellular signals to the nucleus by dephosphorylation of members of the NFAT family of transcription factors. These linkages demonstrate calcineurin/PP2B's multifunctional capabilities in the regulation of calcium signaling. View All» Species Reactivity:

• Mouse

• Human

• Mammals
  View All» Species Reactivity Note: Human and Mouse. Broad reactivity with mammal species is expected. View All» Application Notes: Immunohistochemisty (paraffin): Representative testing from a previous lot. Calcineurin representative staining pattern/morphology in human vascular tissue. Tissue was pretreated with citrate pH 6, antigen retrieval. A previous lot of this antibody was diluted to 1:100, using IHC-Select® Detection with HRP-DAB.Immunoprecipitation: 3 μL per reaction of a previous lot of this antibody was used in Immunoprecipitation.Optimal working dilutions must be determined by end user View All» Control: PC3 cell lysate View All» Quality Assurance: Routinely evaluated by Western Blot on PC3 lysates.Western Blot Analysis: 1:500 dilution of this lot detected PP2B B on 10 μg of PC3 lysates. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal IgG in buffer containing TBS and 40% glycerol as a cryopreservative. View All» Storage Conditions: Stable for 1 year at -20°C in undiluted aliquots from date of receipt; at this temperature the solution will remain unfrozen. Handling Recommendations: Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage. View All» UniProt Number: Q08209 View All» Entrez Gene Number: NM_000944.3 View All» Gene Symbol:
  • PPP3CA

  • CCN1

  • PPP2B

  • CNA1

  • CAN

  • CALNA1

  • CALN

  • CALNA

  • EC 3.1.3.16
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)

    • Immunoprecipitation
      View All» UniProt Summary: FUNCTION: SwissProt: Q08209 # Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1.COFACTOR: Binds 1 Fe(3+) ion per subunit. & Binds 1 zinc ion per subunit.SIZE: 521 amino acids; 58688 Da SUBUNIT: Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with MYOZ1, MYOZ2 and MYOZ3.SUBCELLULAR LOCATION: Nucleus (By similarity). Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity).SIMILARITY: SwissProt: Q08209 ## Belongs to the PPP phosphatase family. PP-2B subfamily. View All» Product Name: Anti-Calcineurin Antibody | 07-1490 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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