货号：07-1477

品牌：Merck Millipore

规格：100Ug

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Rsk1 Antibody | 07-1477 View All» Replaces: 07-1477 is a recommended replacement for AB3190. View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Recognizes p90 RSK1. View All» Molecular Weight: 83 kDa View All» Immunogen: Synthetic peptide corresponding to the c-terminal sequence of human p90 RSK1 (C-LAQRRVRKLPSTTL). View All» Isotype: IgG View All» Background Information: Rsk1, Rsk2, and Rsk3 (ribosomal protein S6 kinase, 90kDa, polypeptide 1,2,3; S6K-alpha 1,2,3) are Ser/Thr kinases which are activated by MAP Kinases, and are alternatively referred to as MAPKAP kinases 1a, 1b, and 1c. Following activation, Rsk isoforms translocate to the nucleus, where Rsk2 phosphorylates Ser10 of Histone H3, a critical step in the stimulation of immediate-early gene expression. Rsk1 is able to phosphorylate Ser133 of CREB, activating it as a transcription factor. Rsk1 activation can be monitored by phosphorylation state specific antibodies directed against sites involved in its activation. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, mouse and rat. View All» Application Notes: Immunoprecipitation: 4 µg of a previous lot of this antibody was used per 1500 µg of crude protein sample in Immunoprecipitation.ELISA: Recommended.Optimal working dilutions must be determined by end user.Western Blot: A previous lot of this antibody was tested on multiple lysates. See datasheet. View All» Control: NIH/3T3 cell lysate View All» Quality Assurance: Routinely evaluated by Western Blot on NIH/3T3 lysates. Western Blot Analysis: 1:500-1:1,000 dilution of this lot detected RSK1 on 10 μg of NIH/3T3 lysates. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal IgG in buffer containing TBS with 0.01% Sodium Azide in 50% glycerol. View All» Storage Conditions: Stable for 1 year at -20°C in undiluted aliquots from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage. View All» UniProt Number: Q15418 View All» Entrez Gene Number: NM_001006665.1 View All» Gene Symbol:
  • RPS6KA1

  • HU-1

  • MAPKAPK1A

  • RSK

  • pp90RSK1

  • RSK-1

  • p90S6K

  • RSK1

  • EC 2.7.11.1
    View All» Alternate Names:
    • 90 kDa ribosomal protein S6 kinase 1

    • MAP kinase-activated protein kinase 1

    • Ribosomal S6 kinase 1

    • Ribosomal protein S6 kinase alpha-1

    • S6K-alpha 1

    • p90-RSK 1

    • Ribosomal protein S6 kinase alpha 1

    • Ribosomal protein S6 kinase, 90kD, 1

    • Ribosmal protein S6 kinase, 90kDa, polypeptide 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation

      • ELISA
        View All» Entrez Gene Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] View All» UniProt Summary: FUNCTION: Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. ENZYME REGULATION: Activated by multiple phosphorylations on threonine and serine residues. SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation. PTM: Autophosphorylated on Ser-380, as part of the activation process. SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. SIMILARITY: Contains 1 AGC-kinase C-terminal domain. SIMILARITY: Contains 2 protein kinase domains. View All» Product Name: Anti-Rsk1 Antibody | 07-1477 View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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