货号：07-1476

品牌：Merck Millipore

规格：

目录价：￥3634.00

市场价格：￥3088.90

会员价格：￥2907.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MEKK1 Antibody | 07-1476 View All» Replaces: AB3186 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes MEKK1. Antibody recognizes ~78 kDa and 180 kDa, corresponding to the apparent molecular masses of MEKK1 protein and cleaved CT fragment when assessed by Western blotting analysis. Other cross reactive bands are detected on immunoblot analysis. Based on predicted sequence homologies, no cross-reactivity with MEKK22 or MEKK3 is expected. View All» Molecular Weight: 78/180 kDa View All» Immunogen: KLH-conjugated synthetic peptide corresponding to mouse MEKK1. View All» Background Information: MEKK1 (also known as Mitogen-activated protein kinase kinase kinase, MEK Kinase or MAP Kinase Kinase Kinase) is member of the serine/threonine protein kinase family and is a target in the JNK and ERK pathways. Phosphorylation of MEKK1 works with other kinases to activate cellular responses to mitogenic and metabolic stimuli. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Reacts with human. Expected to react with mouse and rat based on sequence homology. View All» Control: PC3 cell lysate View All» Quality Assurance: Evaluated by Western Blot in PC3 cell lysate.Western Blot Analysis: A 1:500 dilution of this antibody detected MEKK1 on 10 µg of PC3 cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in borate buffered saline, pH 8.4, with no preservatives. View All» Storage Conditions: Stable for 12 months at -20°C from date of receipt. View All» UniProt Number: Q13233 View All» Entrez Gene Number: NP_036075.2 View All» Gene Symbol:
  • EC 2.7.11.25

  • MAPKKK1

  • MEKK

  • MEKK1

  • OTTHUMP00000065818
    View All» Alternate Names:
    • MAP/ERK kinase kinase 1

    • MAPK/ERK kinase kinase 1

    • MEK kinase 1

    • MEKK 1

    • mitogen-activated protein kinase kinase kinase 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» UniProt Summary: FUNCTION: Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.COFACTOR: Magnesium.ENZYME REGULATION: Activated by autophosphorylation on Thr-1400 and Thr-1412 following oligomerization.SUBUNIT STRUCTURE: Binds both upstream activators and downstream substrates in multimolecular complexes through its N-terminus. Oligomerizes after binding MAP4K2 or TRAF2. Interacts with AXIN1. PTM: Autophosphorylated By similarity.SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.Contains 1 protein kinase domain.Contains 1 RING-type zinc finger.Contains 1 SWIM-type zinc finger. View All» Product Name: Anti-MEKK1 View All» Concentration: see COA for lot specific data View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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