货号:07-1459
品牌:Merck Millipore
规格:EA
目录价:询价
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Description:
Anti-14-3-3 Antibody, 30 & 33 kDa isoforms | 07-1459
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Replaces:
AB1671
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Promotional Text:
Special Shipping Offer on Antibodies100% Performance Guaranteed
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Specificity:
Polyclonal antibody raised in rabbits using a synthetic peptide corresponding to a sequence conserved among 14-3-3 proteins. It reacts with both the 33 kD and 30 kD isoforms of 14-3-3 proteins.
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Molecular Weight:
Approx. 30 kDa, and 33 kDa
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Epitope:
a.a 208-244
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Immunogen:
Synthetic peptide corresponding to rat 14-3-3 epsilon, amino acids 208-244.
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Background Information:
Mammals express seven distinct 14-3-3 isoforms (gamma, epsilon, beta, zeta, sigma, theta, tau) that form multiple homo- and hetero- dimmers, thus rendering 14-3-3 as a key multifunctional regulatory molecule. 14-3-3 isomers have been implicated in several neurological disorders: for example isoforms gamma, epsilon and beta are expressed in the cerebrospinal fluid of Creutzfeldt-Jakob patients, but not patients suffering from other neurological conditions such as Alzheimer's.
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Species Reactivity:
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Rat
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Mouse
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Human
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Species Reactivity Note:
Proven to react with human, mouse and rat.
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Control:
Jurkat cell lysates
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Quality Assurance:
Evaluated by Western Blot in Jurkat cell lysates.Western Blot Analysis: 1:500 dilution of this lot detected 14-3-3 PROTEINS on 10 g of Jurkat lysates.
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Purification Method:
Unpurified rabbit serum
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Presentation:
Rabbit serum in liquid containing no preservatives.
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Storage Conditions:
Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt. Avoid repeated freeze/thaw cycles.
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UniProt Number:
P62258
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Entrez Gene Number:
P62258
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Gene Symbol:
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YWHAE
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KCIP-1
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MDS
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14-3-3E
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MDCR
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FLJ45465
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Alternate Names:
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14-3-3 epsilon
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14-3-3 protein epsilon
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mitochondrial import stimulation factor L subunit
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protein kinase C inhibitor protein-1
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tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation
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protein, epsilon polypeptide
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tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide 2
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
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UniProt Summary:
FUNCTION: SwissProt: P62258 # Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.SIZE: 255 amino acids; 29174 Da SUBUNIT: Homodimer. Interacts with NDEL1 (By similarity). Interacts with HCV core protein.SUBCELLULAR LOCATION: Cytoplasm (By similarity). Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.SIMILARITY: SwissProt: P62258 ## Belongs to the 14-3-3 family.
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Product Name:
Anti-14-3-3, 30 & 33 kDa isoforms
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Antibody Type:
Polyclonal Antibody
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Qty/Pk:
100 μL
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Format:
Serum
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Host:
Rabbit
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