货号：07-1440

品牌：Merck Millipore

规格：EA

目录价：￥4020.00

市场价格：￥3417.00

会员价格：￥3216.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-Paxillin (Tyr118) Antibody | 07-1440 View All» Replaces: AB3837 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Paxillin phosphorylated at Tyr118. View All» Molecular Weight: 65 kDa View All» Epitope: Tyr118 View All» Immunogen: KLH-conjugagted synthetic peptide corresponding to human Paxillin phosphorylated at Tyr118. View All» Modifications: Phosphorylation View All» Background Information: Paxillin, a focal adhesion protein, is involved in focal adhesion formation during cell adhesion and migration. Paxillin contains LD motifs, LIM domains, and SH3-/SH2-binding domains that participate in a variety of protein-protein interactions with kinases, GTPase-activating proteins, and cytoskeletal proteins. Phosphorylation of paxillin occurs at both tyrosine and serine sites. Tyr118 phosphorylation of paxillin occurs in response to focal adhesion kinase (FAK). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Reacts with rat, human and mouse. View All» Control: L6 cell lysate View All» Quality Assurance: Evaluated by Western Blot in L6 cell lysate.Western Blot Analysis: A 1:1000 dilution of this antibody detected Paxillin on 10 µg of L6 cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal antibody in buffer containing 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50% glycerol. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P49023 View All» Entrez Gene Number: NP_000935.1 View All» Gene Symbol:
  • FLJ16691

  • paxillin
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).SUBUNIT STRUCTURE: Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to focal adhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to focal adhesion kinase. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1 By similarity. Binds ASAP2. Interacts with unphosphorylated ITGA4. Interacts with RNF5.SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton. Cell junction › focal adhesion. PTM: Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. SEQUENCE SIMILARITIES: Belongs to the paxillin family.Contains 4 LIM zinc-binding domains. View All» Product Name: Anti-phospho-Paxillin (Tyr118) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://16ao.com/thread-134751.htm
    © Merck Millipore代理07-1440 Anti-phospho-Paxillin (Tyr118) (rab，产品报价联系微信jinshanbio