金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Ala37-Thr794, with a C-terminal 6-His tag Accession #:P70193 N-terminal Sequence Analysis:Ala37 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:84.3 kDa SDS-PAGE:100-105 kDa, reducing conditions Activity:Measured by its ability to bind ErbB4 in a functional ELISA. Laederich, M.B. et al. (2004) J. Biol. Chem. 279:47050.Immobilized rmLRIG1 at 2.5 µg/mL (100 µL/well) can bind rhErbB4 with a linear range of 8 - 500 ng/mL. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: LRIG1 Long Name: Leucine-rich Repeats and Immunoglobulin-like Domains 1 Aliases: Img; LIG1 Entrez Gene IDs: 26018 (Human); 16206 (Mouse); 312574 (Rat) Background: LRIG1 LRIG1 (leucine-rich repeat and Ig-like domain-containing-1) is a 145 kDa type I transmembrane glycoprotein that shares 45 - 50% amino acid (aa) identity with two other mammalian LRIG proteins. LRIG1 shows highest expression in subsets of glial cells in brain, and certain epithelia in liver, stomach, small intestine and skeletal muscle. Within the cell, LRIG1 is expressed in the perinuclear region as well as on the surface. LRIG1 binds ErbB receptors and promotes their ubiquitination, internalization and destruction.