货号：07-1386

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Connective Tissue Growth Factor Antibody | 07-1386 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the mature chain of Connective tissue growth factor. View All» Molecular Weight: In Western Blot, full length CTGF is observed at 38 kDa and CTGF N&C domain is observed at 19 kDa. View All» Epitope: Mature chain View All» Immunogen: Recombinant protein corresponding to the mature chain of human Connective tissue growth factor. View All» Background Information: Connective Tissue Growth Factor (CTGF) is a member of the CNN family of growth factors that are characterized as having cysteine-rich peptides with four specific domains. CTGF was originally identified in endothelial cells as a significant chemotactic and mitogenic factor. Research has revealed CTGF to have several biological properties which include chemotaxis, cell proliferation, promotion of adhesion and the formation of extracellular matrix. It is also necessary for such biological processes as wound healing, scar formation, fibrosis, embryogenesis and angiogenesis. In its role as an inducer of angiogenesis, CTGF has been associated with vascular endothelial growth factor (VEGF). As a result of its pro-fibrotic properties, CTGF is thought to be a promising target for therapy in conditions involving pathological fibrosis such as chronic fibrotic disease, chronic kidney disease and proliferative diabetic retinopathy (PDR). Cell types found to express CTGF are endothelial cells, fibroblasts and vascular smooth-muscle cells. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Primate (98% sequence homolgy). Monkey (97% sequence homology). Porcine and Bovine (93% sequence homology). Rat and mouse (91% sequence homology). View All» Control: Untreated and TGFb1 treated NRK cell lysates View All» Quality Assurance: Evaluated by Western Blot in untreated and TGFb1 treated NRK cell lysates.Western Blot Analysis: 5 µg/mL of this antibody detected Connective tissue growth factor on 10 µg of untreated and TGFb1 treated NRK cell lysates. View All» Purification Method: Protein G purfied View All» Presentation: Purified goat polyclonal in buffer containing Tris-Glycine pH 8.0 with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P29279 View All» Entrez Gene Number: NP_001892.1 View All» Gene Symbol:

• CTGF

• CCN2

• HCS24

• IGFBP8

• NOV2
  View All» Alternate Names:
  • Hypertrophic chondrocyte-specific protein 24

  • connective tissue growth factor

  • insulin-like growth factor-binding protein 8
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. SUBCUNIT STRUCTURE: Monomer.SUBCELLULAR LOCATION: Secreted › extracellular space › extracellular matrix By similarity. Secreted By similarity. SEQUENCE SIMILARITIES: Belongs to the CCN family.Contains 1 CTCK (C-terminal cystine knot-like) domain.Contains 1 IGFBP N-terminal domain.Contains 1 TSP type-1 domain.Contains 1 VWFC domain. View All» Product Name: Anti-Connective Tissue Growth Factor View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Goat View All»
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