货号：07-1382

品牌：Merck Millipore

规格：

目录价：￥3697.00

市场价格：￥3142.45

会员价格：￥2957.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-eEF2 (C-term) Antibody | 07-1382 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes eEf2 at the C-Terminus. View All» Molecular Weight: 95 kDa View All» Epitope: C-terminus View All» Immunogen: KLH conjugated linear peptide. View All» Background Information: eEF2 (eukaryotic translation elongation factor 2) is essential for protein synthesis. It promotes the GTP-dependent translocation during peptide chain elongation. eEF2 is phosphorylated and inhibited by eEF2 kinase (eEF2K) on Thr56. eEF2K activity is inhibited by phosphorylation by both mTOR and p70S6K. This in turn up regulates eEF2 activity and protein synthesis. Similarly, AMPK down regulates protein synthesis by inhibited the activity of both p70S6K and mTOR, through TSC2. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Proven to react with human, mouse and rat. View All» Application Notes: Immunohistochemistry: 1:100 – 1:250 dilution of a previous lot was used on immunohistochemistry.Immunocytochemistry: 1:50 – 1:100 dilution of a previous lot was used on immunocytochemistry.Immunoprecipitation: 1:50 dilution of a previous lot was used on immunoprecipitation.Flow Cytometry: 1:20 dilution of a previous lot was used on flow cytometry. View All» Control: HEK293 cell lysate. View All» Quality Assurance: Routinely evaluated by Western Blot on HEK293 cell lysate.Western Blot Analysis: A 1:50,000 dilution of this lot was to detect eEF2 on HEK293 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Unpurified rabbit polyclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P13639 View All» Entrez Gene Number: NP_001952 View All» Gene Symbol:
  • EEF-2

  • EF-2

  • EF2
    View All» Alternate Names:
    • eukaryotic translation elongation factor 2

    • polypeptidyl-tRNA translocase
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry

      • Immunohistochemistry

      • Flow Cytometry

      • Immunoprecipitation
        View All» Entrez Gene Summary: This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. View All» UniProt Summary: FUNCTION: This protein promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome.LOCATION: Cytoplasm. PTM: Phosphorylation by EF-2 kinase completely inactivates EF-2.Diphthamide is 2-[3-carboxyamido-3-(trimethyl-ammonio)propyl]histidine. Diphthamide can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A.SIMILARITY: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily. View All» Product Name: Anti-eEF2 (C-term) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Unpurified View All» Host: Rabbit View All»
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