货号：07-1356

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-acetyl-PRLR (Lys277) Antibody | 07-1356 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes PRLR when acetylated at Lys277. View All» Molecular Weight: 70 kDa calculated. Uncharacterized bands at increased sizes may be due to post-translational modifications. Uniprot also lists three potential glycosylation sites as well as 8 isoforms ranging in size from ~25 kDa to ~58 kDa. View All» Epitope: Acetylated Lys277 View All» Immunogen: KLH-conjugated linear peptide corresponding to the cytoplasmic domain of PRLR acetylated at Lys277. View All» Modifications: Acetylation View All» Background Information: PRLR (prolactin receptor) is the receptor for prolactin and is essential for embryo implantation and early pregnancy. PRLR and prolactin seem to be involved in all aspects of female reproductive function in mammals. PRLR is thought to be controlled by ovarian steroid hormones in the fallopian tubes. Ligand binding to PRLR is thought to play a role in the growth of malignant breast tissue and may be useful for future therapies. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Other homologies: Rat and Mouse (90% sequence homology). View All» Application Notes: Western Blot Analysis: A representative lot of this antibody was used by an independent laboratory in WB. (Ma, L., et al. (2010). Proc Natl Acad Sci. 107(45):19314-19319.) View All» Control: Modified and non modified peptides of acetylated and non-acetylated PRLR protein. View All» Quality Assurance: Evaluated by Dot Blot in modified and non modified peptides of acetylated and non-acetylated PRLR protein.Dot Blot Analysis: 2 µg/mL of this antibody detected PRLR in modified and non modified peptides of acetylated and non-acetylated PRLR protein. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P16471 View All» Entrez Gene Number: NP_000940 View All» Gene Symbol:

• PRLR

• PRL-R

• hPRLr
  View All» Alternate Names:
  • Prolactin receptor

  • delta 4-delta 7/11 truncated prolactin receptor

  • hPRL receptor

  • secreted prolactin binding protein

  • delta 4-SF1b truncated prolactin receptor

  • prolactin receptor delta 7/11
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Dot Blot

    • Western Blotting
      View All» Entrez Gene Summary: Summary: This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.SUBUNIT STRUCTURE: Homodimer upon hormone binding. Interacts with SMARCA1. Interacts with GH1. Interacts with CSH.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Isoform 7: Secreted. TISSUE SPECIFICITY: Expressed in breast, placenta, kidney, liver and pancreas. DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation.SEQUENCE SIMILARITIES: Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 2 fibronectin type-III domains. View All» Product Name: Anti-acetyl-PRLR (Lys277) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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