货号：07-1282

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-PRAS40 (Thr246) Antibody | 07-1282 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Detects PRAS40 when phosphorylated on Thr246. View All» Molecular Weight: 40 kDa View All» Epitope: Phosphorylated Thr246 View All» Immunogen: KLH-conjugated synthetic linear peptide corresponding to the amino acids surrounding and including phosphorylated Thr246 of human PRAS40. View All» Modifications: Phosphorylation View All» Background Information: PRAS40 (Proline Rich Akt Substrate, 40kDa), also known as AKT1S1, is a ubiquitously express protein that is phosphorylated on residue Thr246 via the PI3K/Akt pathway. It was originally discovered as an Akt substrate as it has the putative Akt phosphorylation motif. This phosphorylation allows it to bind 14-3-3 and Raptor of the mTOR complex mTORC1. PRAS40 is known to bind to and regulate mTORC1 (mTOR, Raptor, mLST8) kinases activity that is activated by insulin downstream of PI3K and Akt and subsequently phosphorylates p70S6K and 4EBP1. PRAS40 is known to have a putative TOS motif (FVMDE) that allows it bind to Raptor of mTORC1. It is thought that through its binding to the Raptor, PRAS40 inhibits the kinase activity of mTORC1 by preventing to bind to its substrates such as p70S6K and 4EBP1. View All» Species Reactivity:

• Mouse

• Rat

• Human

• Bovine
  View All» Species Reactivity Note: Rat and Mouse. Predicted to cross-react with human and bovine based sequence homology of immunizing peptide. View All» Quality Assurance: Evaluated by western blot on untreated and Insulin-treated NIH/3T3 cell lysateWestern Blot Analysis: 1:2,000 dilution of this antibody was used to detect PRAS40 in Insulin-treated NIH/3T3 cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Antigen affinity purified rabbit serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. View All» UniProt Number: Q96B36 View All» Entrez Gene Number: NM_026270.3 View All» Gene Symbol:
  • Lobe

  • MGC2865

  • PRAS40
    View All» Alternate Names:
    • 40 kDa proline-rich AKT substrate

    • AKT1 substrate 1 (proline-rich)

    • proline-rich Akt substrate, 40 kDa
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: May play an important role in phosphatidylinositol 3-kinase (PI3K)-AKT1 survival signaling. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. Its role in survival signaling pathways may be modulated by oxidative stress. May also play a role in nerve growth factor-mediated neuroprotection. SUBUNIT STRUCTURE: The phosphorylated form interacts with 14-3-3. SUBCELLULAR LOCATION: Cytoplasm › cytosolBy similarity. Note= Found in the cytosolic fraction of the brain By similarity.TISSUE SPECIFICITY: Widely expressed with highest levels of expression in liver and heart. Expressed at higher levels in cancer cell lines (e.g. A549 and HeLa) than in normal cell lines (e.g. HEK293). View All» Product Name: Anti-phospho-PRAS40 (Thr246) View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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