货号：07-1217

品牌：Merck Millipore

规格：100Ug

目录价：￥5249.00

市场价格：￥4461.65

会员价格：￥4199.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PP1β Antibody | 07-1217 View All» Replaces: 07-1217 is a recommended replacement for AB4083 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes Protein Phosphatase 1β. No cross reactivity with other recombinant PP1 isoforms. View All» Molecular Weight: ~ 38kDa View All» Epitope: C-terminus View All» Immunogen: The immunogen used to the purified peptide conjugated to KLH corresponding to the C-terminus of PP1 beta catalytic subunit (amino acids 318-327). View All» Isotype: IgG View All» Background Information: Type 1 protein Ser/Thr phosphatases (PP1) have a high specific activity against phosphorylase, and are resistant to okadaic acid up to concentrations of 50 nM, but sensitive to Inhibitor-2 and microcystin LR. View All» Species Reactivity:

• Bovine

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Bovine,Human, Mouse, Rat. View All» Application Notes: Immunoprecipitation: A previous lot of this antibody was used in immunoprecipitation at a dilution of 10-15μg/mL.Immunohistochemistry(paraffin):Optimal Staining of PP1beta Polyclonal Antibody: Human Testis PP1beta staining in normal human testis, tissue pretreated with citrate buffer, pH 6.0. A previous lot of this antibody was diluted to 1:100, using IHC-Select® detection with HRP-DAB. View All» Control: HeLa Cell Lysate View All» Quality Assurance: Routinely evaluated by Western Blot on HeLa lysates.Western Blot Analysis: 1:500 dilution of this lot detected PP-1beta on 10 μg of HeLa lysates. View All» Purification Method: Purified View All» Presentation: Purified rabbit polyclonal IgG provided as 0.2µm sterile filtered solution in phosphate buffered saline with 0.08% sodium azide. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 1 year from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P62140 View All» Entrez Gene Number: NM_206877 View All» Gene Symbol:
  • PPP1CB

  • PP-1B

  • PPP1CD

  • MGC3672

  • EC 3.1.3.16
    View All» Alternate Names:
    • Serine/threonine-protein phosphatase PP1-beta catalytic subunit

    • Protein phosphatase 1, catalytic subunit, beta

    • Protein phosphatase 1, catalytic subunit, beta isoform

    • Protein phosphatase 1-beta

    • Protein phosphatase 1-delta
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. View All» UniProt Summary: FUNCTION: SwissProt: P62140 # Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity.COFACTOR: Binds 1 iron ion per subunit (By similarity). & Binds 1 manganese ion per subunit (By similarity).SIZE: 327 amino acids; 37187 Da SUBUNIT: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A and PPP1R12B mediate binding to myosin. PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen (By similarity). Interacts with PPP1R7.SUBCELLULAR LOCATION: Cytoplasm (By similarity).SIMILARITY: SwissProt: P62140 ## Belongs to the PPP phosphatase family. PP-1 subfamily. View All» Brand Family: Upstate View All» Product Name: Anti-PP1β Antibody | 07-1217 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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