货号：07-1216

品牌：Merck Millipore

规格：100UL

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PP2A Antibody, Catalytic subunit | 07-1216 View All» Replaces: 07-1216 is a recommended replacement for AB1621. View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes protein phosphatase 2A, catalytic subunit. View All» Molecular Weight: 60 kDa View All» Epitope: C-terminus View All» Immunogen: Synthetic peptide corresponding to a.a. 298-309 of the human sequence. View All» Isotype: IgG View All» Background Information: PP2A is a type 2 protein Ser/Thr phosphatase characterized by high activity against the α subunit of Phosphorylase Kinase and low sensitivity to Inhibitor-2. PP2A is distinguishable from PP2B/Calcineurin and PP2C by its partial activity in the absence of divalent cations, and its high sensitivity to Okadaic Acid. It is also thought to be the principal downmodulator of Ser/Thr kinase cascades. PP2A is a heterotrimer containing a structural subunit (A), a regulatory subunit (B), and a catalytic subunit (C). There are multiple isotypes (encoded by distinct genes) of the B subunit, grouped into three families: B/PR55, B'/PR61, and B''/PR72 . PTPA is a member of the B' family that is required for activation of PP2A by an undefined mechanism. View All» Species Reactivity:

• Bovine

• Chicken

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Peptide is highly conserved in human, rat, bovine, mouse and chicken. View All» Application Notes: Immunohistochemisty (paraffin): Antibody was diluted to 1:100, using IHC-Select® Detection with HRP-DAB. Immunoreactivity is seen as staining in normal human testis. View All» Control: HEK293 cell lysate View All» Quality Assurance: Routinely evaluated by Western Blot on HEK293 lysates. Western Blot Analysis: 1:500-1:1,000 dilution is traditonally used to detected PP2A, Catalytic subunit in 10 μg of HEK293 lysates. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal IgG in buffer containing PBS with no preservatives. View All» Storage Conditions: Stable for 1 year at -80°C from date of receipt. Avoid repeated freeze/thaw. View All» UniProt Number: Q14738 View All» Entrez Gene Number: NM_006245 View All» Gene Symbol:
  • PPP2R5D

  • MGC8949

  • MGC2134

  • OTTHUMP00000039821

  • B56D
    View All» Alternate Names:
    • Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, delta isoform

    • Delta isoform of regulatory subunit B56, protein phosphatase

    • Protein phosphatase 2, regulatory subunit B (B56), delta isoform

    • Protein phosphatase 2, regulatory subunit B', delta isoform
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. View All» UniProt Summary: FUNCTION: SwissProt: Q14738 # The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.SIZE: 602 amino acids; 69992 Da SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Nuclear in interphase, nuclear during mitosis.TISSUE SPECIFICITY: Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY: SwissProt: Q14738 ## Belongs to the phosphatase 2A regulatory subunit B56 family. View All» Brand Family: Upstate View All» Product Name: Anti-PP2A Antibody, Catalytic subunit | 07-1216 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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