货号：07-108

品牌：Merck Millipore

规格：200UL

目录价：￥6742.00

市场价格：￥5730.70

会员价格：￥5393.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Histone H4 Antibody | 07-108 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes Histone H4, Mr 10 kDa. View All» Molecular Weight: 10 kDa View All» Immunogen: Calf thymus histone H4. View All» Isotype: IgG View All» Background Information: Histone H4 is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N terminal tail H4 is involved with the structure of the nucleosomes of the 'beads on a string' structure. View All» Species Reactivity:

• Mouse

• Human

• Bovine

• Avian

• Chicken

• Xenopus
  View All» Species Reactivity Note: Human, mouse, bovine, chicken and Xenopus. Broad species cross-reactivity expected. View All» Control: HeLa cell extract. View All» Quality Assurance: Routinely evaluated by western blot on acid extracts of HeLa cells treated with sodium butyrate.Western Blot Analysis: 0.1-0.5 μg/mL of this lot detected Histone H4 in acid extracts of HeLa cells treated with or without 5 mM sodium butyrate. This lot did not cross react with Histone H2A, Histone H2B or Histone H3. View All» Purification Method: Protein A chromatography View All» Presentation: Purified rabbit polyclonal IgG in buffer containing 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% Sodium Azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. View All» UniProt Number: P62805 View All» Entrez Gene Number: NP_778224 View All» Gene Symbol:
  • HIST1H4A

  • H4/J

  • HIST1H4F

  • HIST1H4L

  • H4FN

  • H4FA

  • H4FH

  • HIST1H4H

  • H4F2

  • H4FM

  • H4/A

  • H4FK

  • H4FG

  • HIST2H4

  • H4FB

  • H4/K

  • HIST1H4I

  • H4/N

  • HIST1H4B

  • H4FE

  • H4/M

  • H4/a

  • HIST1H4E

  • HIST4H4

  • HIST2H4A

  • H4FC

  • H4FI

  • H4/H

  • HIST1H4C

  • H4/G

  • HIST1H4K

  • H4FJ

  • H4FD

  • H4/I

  • H4/B

  • H4/D

  • H4/C

  • HIST1H4J

  • HIST1H4D

  • H4/E
    View All» Alternate Names:
    • H4 histone family, member A

    • histone 1, H4a

    • histone cluster 1, H4a
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. View All» UniProt Summary: FUNCTION: SwissProt: P62805 # Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.SIZE: 103 amino acids; 11367 Da SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.SUBCELLULAR LOCATION: Nucleus.PTM: Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By similarity). & Ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation. This may weaken the interaction between histones and DNA and facilitate DNA accessibility to repair proteins.SIMILARITY: SwissProt: P62805 ## Belongs to the histone H4 family. View All» Brand Family: Upstate View All» Product Name: Anti-Histone H4 Antibody | 07-108 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Purified View All» Host: Rabbit View All»
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