货号：06-972

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Wee1 Antibody | 06-972 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Wee1 View All» Molecular Weight: 105kDa View All» Immunogen: residues to 215-646 of human Wee1 View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse
  View All» Quality Assurance: routinely evaluated by immunoblot on in RIPA lysates from unstimulated A431 cells View All» Purification Method: Imunoaffinity chromatography View All» Presentation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 5mg/ml BSA and 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 1 year at -20°C View All» UniProt Number: P30291 View All» Entrez Gene Number: NM_003390 View All» Gene Symbol:
  • WEE1

  • WEE1hu

  • FLJ16446

  • DKFZp686I18166
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. View All» UniProt Summary: FUNCTION: SwissProt: P30291 # May act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDC2 before the onset of mitosis. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Specifically phosphorylates and inactivates cyclin B1-complexed CDC2 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDC2 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDC2 does not occur.COFACTOR: Binds 2 magnesium ions per subunit.SIZE: 646 amino acids; 71597 Da SUBCELLULAR LOCATION: Nucleus.PTM: Phosphorylated during M and G1 phases. Also autophosphorylated. & Ubiquitinated and degraded at the onset of G2/M phase (By similarity).SIMILARITY: SwissProt: P30291 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Product Name: Anti-Wee1 Antibody | 06-972 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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