货号：06-953

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-FKHRL1 (Ser253) Antibody | 06-953 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: FKHRL1 phosphorylated on serine 253 View All» Molecular Weight: 100kDa View All» Immunogen: KLH-conjugated, synthetic peptide corresponding to the N-Terminus of human FKHRL1 View All» Modifications: Phosphorylation View All» Isotype: IgG View All» Species Reactivity: Mouse View All» Quality Assurance: routinely evaluated by immunoblot on lysates from PDGF treated NIH/3T3 cells View All» Purification Method: Immunoaffinity purified View All» Presentation: 0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH7.4. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O43524 View All» Entrez Gene Number: NM_001455 View All» Gene Symbol:

• FOXO3

• FKHRL1

• FOXO2

• AF6q21

• DKFZp781A0677

• MGC12739

• FOXO3A

• FKHRL1P2

• MGC31925
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. View All» UniProt Summary: FUNCTION: SwissProt: O43524 # Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'.SIZE: 673 amino acids; 71277 Da SUBUNIT: Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration. Upon oxidative stress, interacts with STK4, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation.SUBCELLULAR LOCATION: Cytoplasm, cytosol. Note=Translocates to the nucleus upon oxidative stress and in the absence of survival factors.TISSUE SPECIFICITY: Ubiquitous.PTM: In the presence of survival factors such as IGF-1, phosphorylated on Thr-32 and Ser-253 by AKT1/PKB. This phosphorylated form then interacts with 14-3-3 proteins and is retained in the cytoplasm. Survival factor withdrawal induces dephosphorylation and promotes translocation to the nucleus where the dephosphorylated protein induces transcription of target genes and triggers apoptosis. Although AKT1/PKB doesn't appear to phosphorylate Ser-315 directly, it may activate other kinases that trigger phosphorylation at this residue. Phosphorylated by STK4 on Ser-209 upon oxidative stress, which leads to dissociation from YWHAB/14-3-3-beta and nuclear translocation.DISEASE:SwissProt: O43524 # A chromosomal aberration involving FOXO3 is found in secondary acute leukemias. Translocation t(6;11)(q21;q23) with MLL/HRX.SIMILARITY: SwissProt: O43524 ## Contains 1 fork-head DNA-binding domain. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-FKHRL1 (Ser253) Antibody | 06-953 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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