货号：06-878

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Mi-2 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Mi2 View All» Molecular Weight: 218kDa View All» Immunogen: Fusion protein corresponding to amino acid residues 474-970 of human Mi-2 View All» Isotype: IgG View All» Species Reactivity: Human View All» Quality Assurance: routinely evaluated by immunoblot on Hela nuclear extract View All» Purification Method: Protein A chromatography View All» Presentation: 0.014M phosphate buffer, pH 7.6, 0.175M NaCl, 0.07% sodium azide, and 30% glycerol. View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: Q12873 View All» Entrez Gene Number: NM_001005273 View All» Gene Symbol:

• CHD3

• hZFH

• CHD-3

• ZFH

• Mi2-alpha

• Mi2-ALPHA

• Mi-2a
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. View All» UniProt Summary: FUNCTION: SwissProt: Q12873 # Probable transcription regulator.SIZE: 2000 amino acids; 226592 Da SUBUNIT: Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressive complex. Interacts with TRIM28 and SERBP1. Interacts via its C-terminal region with HABP4.SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Widely expressed.DISEASE:SwissProt: Q12873 # One of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis.SIMILARITY: SwissProt: Q12873 ## Belongs to the SNF2/RAD54 helicase family. & Contains 2 chromo domains. & Contains 1 helicase ATP-binding domain. & Contains 1 helicase C-terminal domain. & Contains 2 PHD-type zinc fingers. View All» Brand Family: Upstate View All» Product Name: Anti-Mi-2 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Rabbit View All»
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