货号：06-727

品牌：Merck Millipore

规格：200Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FcεRI Antibody, γ subunit | 06-727 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes and is specific for FcεRI, γ-subunit, MW 10kDa. View All» Molecular Weight: 30 kDa View All» Immunogen: Synthetic peptide KHEKPPQ corresponding to amino acids 80-86 of γ-subunit of Fc receptors. View All» Isotype: IgG View All» Background Information: Type I allergic reactions are mediated through the IgE high affinity receptor (FceRI). When a multivalent antigen is presented, a redistribution of the monomeric IgE FceRI receptor complexes cause the degranulation of mast cells and basophils, resulting in the subsequent release of factors responsible for type I allergic reactions. The FceRI receptor is a tetrameric complex, consisting of an a-chain, b-chain and a dimeric g-chain. While the a-chain is primarily involved with the binding of IgE, the signal is transferred through the g subunit, which contains the immunoreceptor tyrosine activation motifs (ITAM) critical for initiating receptor mediated signal transduction through the Syk and Lyn tyrosine kinases. The FceRI receptor is able to engage and disengage the IgE, providing a versatile model for studying the function of kinase coupled receptors. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, rat and mouse. Other species cross-reactivity not tested. View All» Application Notes: Immunoprecipitation: Reported to immunoprecipitate FcεR1, γ-subunit from RBL cells. View All» Control: RBL cell lysate View All» Quality Assurance: Evaluated by western blot on RIPA lysate of RBL cells.Western Blot Analysis: 0.5-2 μg/mL of this antibody detected FcεRI, γ-subunit in RIPA lysate of RBL cells. View All» Purification Method: Protein A purfied View All» Presentation: Purified rabbit polylclonal IgG in buffer containing 70% storage buffer (0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide) and 30% glycerol. View All» Storage Conditions: Stable for 1 year at from date of receipt. View All» UniProt Number: P30273 View All» Entrez Gene Number: NP_001992.1 View All» Gene Symbol:
  • FCER1G

  • OTTHUMP00000063478
    View All» Alternate Names:
    • Fc fragment of IgE, high affinity I, receptor for, gamma polypeptide

    • Fc fragment of IgE, high affinity I, receptor for

    • gammapolypeptide

    • Fc-epsilon RI-gamma

    • FceRI gamma

    • IgE Fc receptor subunit gamma

    • immunoglobulin E receptor, high affinity, gamma chain
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation
        View All» Entrez Gene Summary: The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139); only the alpha subunit is glycosylated. View All» UniProt Summary: FUNCTION: SwissProt: P30273 # The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface.SIZE: 86 amino acids; 9667 Da SUBUNIT: IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.SIMILARITY: SwissProt: P30273 ## Belongs to the CD3Z/FCER1G family. & Contains 1 ITAM domain. View All» Brand Family: Upstate View All» Product Name: Anti-FcεRI Antibody, γ subunit | 06-727 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 μg View All» Format: Purified View All» Host: Rabbit View All»
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