货号：06-725

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FcεRI α subunit Antibody | 06-725 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: FcεRIα View All» Molecular Weight: 45 kDa View All» Immunogen: extracellular portion of the α chain of the human high-affinity receptor for immunoglobulin E (FceRI) View All» Isotype: IgG View All» Species Reactivity: Human View All» Quality Assurance: routinely evaluated by immunoblot on cell lysate from CHO cells transfected with the human α, β and γ subunits of FcεRI View All» Purification Method: Antiserum View All» Presentation: rabbit antiserum containing 0.05% sodium azide View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P12319 View All» Entrez Gene Number: NM_002001 View All» Gene Symbol:

• FCER1A

• FcERI

• FCE1A
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Flow Cytometry

  • Western Blotting
    View All» Entrez Gene Summary: The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139); only the alpha subunit is glycosylated.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P12319 # Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.SIZE: 257 amino acids; 29596 Da SUBUNIT: Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.SIMILARITY: SwissProt: P12319 ## Contains 2 Ig-like (immunoglobulin-like) domains. View All» Brand Family: Upstate View All» Product Name: Anti-FcεRI α subunit Antibody | 06-725 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Serum View All» Host: Rabbit View All»
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