货号：06-647

品牌：Merck Millipore

规格：200Ug

目录价：￥4396.00

市场价格：￥3736.60

会员价格：￥3516.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Flt-3 Antibody, cytoplasmic domain | 06-647 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: premature and the mature forms of Flt3 View All» Molecular Weight: premature (130kDa) and the mature form (155kDa) View All» Immunogen: His-tag fusion protein corresponding to residues 786-1000 of mouse Flt3 View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse
  View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from HeLa cells or mouse Bafl-3 cells View All» Purification Method: Protein A chromatography View All» Presentation: 0.07M Tris-glycine, pH 7.4, 0.105M NaCl and 0.035% sodium azide, and 30% glycerol. View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P36888 View All» Entrez Gene Number: NM_004119 View All» Gene Symbol:
  • FLT3

  • STK-1

  • CD135

  • FLK2

  • OTTHUMP00000042340

  • STK1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. View All» UniProt Summary: FUNCTION: SwissProt: P36888 # Receptor for the FL cytokine. Has a tyrosine-protein kinase activity.SIZE: 993 amino acids; 112903 Da SUBUNIT: Interacts with FIZ1 following ligand activation (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Bone marrow cells.SIMILARITY: SwissProt: P36888 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 1 Ig-like C2-type (immunoglobulin-like) domain. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Product Name: Anti-Flt-3 Antibody, cytoplasmic domain | 06-647 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Rabbit View All»
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