货号：06-417

品牌：Merck Millipore

规格：

目录价：￥3545.00

市场价格：￥3013.25

会员价格：￥2836.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-AKAP 95 Antibody | 06-417 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: AKAP 95 View All» Molecular Weight: 95kDa View All» Immunogen: Recombinant mouse AKAP expressed in E. coli View All» Isotype: IgG View All» Background Information: A-kinase anchor proteins (AKAPs) function to localize the cAMP-dependent protein kinase (PKA) to specific subcellular sites. Anchoring of PKA is an efficient means to adapt the kinase for specific cAMP-responsive events as it permits rapid and preferential phosphorylation of target substrates upon elevation of cAMP. So far, 35 unique AKAPs have been identified which function to tether the kinase to a variety of cellular structures and organelles. AKAP95 is a 95kDa protein which is a component of the nuclear matrix in all cell-lines. View All» Species Reactivity:

• Human

• Rat
  View All» Control: Included Positive Antigen Control: Catalogue No. 12-309, HeLa nuclear extract cell lysate. Use 20μg per lane for minigels. View All» Quality Assurance: routinely evaluated by immunoblot on human A431 lysates or HeLa nuclear extract View All» Purification Method: Protein G chromatography View All» Presentation: Liquid in 200 μL 0.1M Tris-glycine, pH 7.4 View All» Storage Conditions: 2 years at -20°C from date of shipment. Stable for 6 months at 4°C. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the vial after thawing and prior to removing cap. View All» UniProt Number: O43823 View All» Entrez Gene Number: NM_005858 View All» Gene Symbol:
  • AKAP8

  • DKFZp586B1222

  • AKAP95
    View All» Alternate Names: A-Kinase Anchor Protein 95 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Western Blotting
      View All» Entrez Gene Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is located in the nucleus during interphase and is distinctly redistributed during mitosis. This protein has a cell cycle-dependent interaction with the RII subunit of PKA. View All» UniProt Summary: FUNCTION: SwissProt: O43823 # Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II).SIZE: 692 amino acids; 76108 Da SUBUNIT: Binds to dimeric RII-alpha regulatory subunit of PKA during mitosis.SUBCELLULAR LOCATION: Nucleus matrix. Note=Associated with the nuclear matrix. Redistributed and detached from condensed chromatin during mitosis.TISSUE SPECIFICITY: Highly expressed in heart, liver, skeletal muscle, kidney and pancreas.SIMILARITY: SwissProt: O43823 ## Belongs to the AKAP95 family. View All» Brand Family: Upstate View All» Product Name: Anti-AKAP 95 Antibody | 06-417 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Rabbit View All»
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