货号：06-408

品牌：Merck Millipore

规格：

目录价：￥4224.00

市场价格：￥3590.40

会员价格：￥3379.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-14-3-3 ζ/γ/η Antibody | 06-408 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: zeta, gamma and eta isoforms of 14-3-3 View All» Molecular Weight: 27kDa View All» Immunogen: HPLC-purified synthetic peptide (KMKGDYYRYLAE) corresponding to the zeta, gamma and eta isoforms of 14-3-3 View All» Isotype: IgG View All» Species Reactivity: Vertebrates View All» Quality Assurance: routinely evaluated by immunoblot on a preparation of bovine brain cytosol View All» Purification Method: Antiserum View All» Presentation: rabbit antiserum View All» Storage Conditions: 2 years at -20°C View All» UniProt Number:

• P63104

• P40763

• Q04917
  View All» Entrez Gene Number: NM_003406 View All» Gene Symbol:
  • YWHAZ

  • KCIP-1

  • MGC126532

  • MGC111427

  • MGC138156
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat has been associated with early-onset schizophrenia. View All» UniProt Summary: FUNCTION: SwissProt: P40763 # Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.SIZE: 770 amino acids; 88068 Da SUBUNIT: Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with NCOA1, PELP1, SOCS7 and STATIP1. Interacts with HCV core protein. Interacts with IL23R in presence of IL23. Interacts with IL31RA.SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.TISSUE SPECIFICITY: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.PTM: Tyrosine phosphorylated in response to IL-6, IL-11, CNTF, LIF, CSF-1, EGF, PDGF, IFN-alpha and OSM. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity.DISEASE: "SwissProt: P40763 # Defects in STAT3 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal dominant (AD-HIES) [MIM:147060]; also known as hyper-IgE syndrome or Job syndrome. AD-HIES is a rare disorder of immunity and connective tissue characterized by immunodeficiency, chronic eczema, recurrent Staphylococcal infections, increased serum IgE, eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures."SIMILARITY: SwissProt: P40763 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.MISCELLANEOUS: Involved in the gp130-mediated signaling pathway." View All» Brand Family: Upstate View All» Product Name: Anti-14-3-3 ζ/γ/η Antibody | 06-408 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 150 µL View All» Format: Serum View All» Host: Rabbit View All»
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