货号：06-172

品牌：Merck Millipore

规格：

目录价：￥4481.00

市场价格：￥3808.85

会员价格：￥3584.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Na+/K+ ATPase α-3 Antibody | 06-172 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Na⁺/K⁺ ATPase α-3 View All» Molecular Weight: 112kDa View All» Immunogen: Fusion protein derived the alpha 3 subunit containing residues 320-514 View All» Isotype: IgG View All» Species Reactivity: Rat View All» Quality Assurance: routinely evaluated by immunoblot on brain microsomal preparations View All» Purification Method: Protein A chromatography View All» Presentation: 0.1M Tris-HCl, pH 7.2, containing 0.02% sodium azide View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P13637 View All» Entrez Gene Number: NM_152296 View All» Gene Symbol:

• ATP1A3

• MGC13276

• RDP

• IIIsubunit).

• DYT12

• +K

• Na
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunohistochemistry

  • Western Blotting
    View All» Entrez Gene Summary: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. View All» UniProt Summary: FUNCTION: SwissProt: P13637 # This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.SIZE: 1013 amino acids; 111749 Da SUBUNIT: Composed of three subunits: alpha (catalytic), beta and gamma.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.DISEASE: SwissProt: P13637 # Defects in ATP1A3 are the cause of dystonia-12 (DYT12) [MIM:128235]; also known as rapid-onset dystonia parkinsonism (RDP). DYT12 is an autosomal dominant form of dystonia- parkinsonism characterized by an unusually rapid evolution of signs and symptoms. Affected persons develop dystonia and parkinsonism between 14 and 45 years of age. The sudden onset of symptoms over hours to a few weeks, often associated with physical or emotional stress, suggests a trigger initiating a nervous system insult resulting in permanent neurologic disability.SIMILARITY: SwissProt: P13637 ## Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily. View All» Brand Family: Upstate View All» Product Name: Anti-Na+/K+ ATPase α-3 Antibody | 06-172 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 125 µg View All» Target / Localization: All neurons View All» Format: Purified View All» Host: Rabbit View All»
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