货号：06-138

品牌：Merck Millipore

规格：200Ug

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cyclin A Antibody | 06-138 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: p58cyclin A; does not cross-react with cyclin B or cyclin D2, or 3 View All» Molecular Weight: 58kDa View All» Immunogen: peptide corresponding amino acid residues 417-432 (C-KHGVSLLNPPETL-N-L) View All» Isotype: IgG View All» Background Information: The cell cycle is regulated by the interplay of many molecules. Key among these are the cyclins which are expressed and then degraded in a concerted fashion to drive the stages of the cell cycle. Cyclins combine with cyclin dependent kinases (cdks) to form activated kinases that phosphorylate targets leading to cell cycle regulation. A breakdown in the regulation of this cycle can lead to out of control growth and contribute to tumor formation. Defects in many of the molecules that regulate the cell cycle have been implicated in cancer. Cyclin A is a member of the Cyclin A family that can bind and activate Cdc2 and Cdk2 and is involved in the control of mitosis and S phase. During S phase, cyclin A forms a complex with Cdk2, the pRB-related protein p107 and E2F. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Sheep
  View All» Control: Daudi cells View All» Quality Assurance: routinely evaluated by immunoblot on HeLa nuclear extract View All» Purification Method: Protein G chromatography View All» Presentation: Lyophilized View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P20248 View All» Entrez Gene Number: NM_001237 View All» Gene Symbol:
  • CCNA2

  • Cyclin-A2

  • CCN1

  • Cyclin-A

  • CCNA
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. View All» UniProt Summary: FUNCTION: SwissProt: P20248 # Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.SIZE: 432 amino acids; 48537 Da SUBUNIT: Interacts with the CDK2 and CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.DEVELOPMENTAL STAGE: Accumulates steadily during G2 and is abruptly destroyed at mitosis.SIMILARITY: SwissProt: P20248 ## Belongs to the cyclin family. Cyclin AB subfamily. View All» Brand Family: Upstate View All» Product Name: Anti-Cyclin A Antibody | 06-138 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Rabbit View All»
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