货号：06-1366

品牌：Merck Millipore

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目录价：￥3789.00

市场价格：￥3220.65

会员价格：￥3031.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SRp55 Antibody | 06-1366 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~50 kDa observed. Mulitple uncharacterized bands have been observed in some lysates. View All» Immunogen: KLH-conjugated linear peptide corresponding to human SRp55. View All» Background Information: Pre-mRNA-splicing factor SRp55, also known as Serine/arginine-rich splicing factor 6, is a member of the serine/arginine-rich (SR) protein family. This group of proteins is found mainly in the nucleus where they play a critical role in regulated and constitutive splicing of precursor mRNAs. SRp55 is involved in the constitutive process for mRNA splicing, and is able to mediate alternative splice site selection. Considered one of the more ubiquitous of the splice factors, SRp55 is upregulated in response to DNA damage when p53 is lacking. SRp55 is significantly phosphorylated on RS domain serine residues. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in IP. (Jiang, K., et al. (2009). Endocrinology. 150(5):2087-2097.) View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 1:500 dilution of this antibody detected SRp55 on 10 µg of HeLa cell lysate. View All» Purification Method: Protein A View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q13247 View All» Entrez Gene Number: NP_006266 View All» Gene Symbol:

• SRP55

• SFRS6

• SRSF6

• B52
  View All» Alternate Names:
  • serine/arginine-rich splicing factor 6

  • splicing factor, arginine/serine-rich 6

  • arginine/serine-rich splicing factor 6

  • splicing factor, arginine/serine-rich, 55 kDa

  • Pre-mRNA-splicing factor SRP55

  • pre-mRNA splicing factor SRP55

  • SR splicing factor 6
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunoprecipitation
      View All» Entrez Gene Summary: The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene. View All» UniProt Summary: FUNCTION: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.SUBUNIT STRUCTURE: Binds SFRS12.SUBCELLULAR LOCATION: Nucleus. PTM: Extensively phosphorylated on serine residues in the RS domain (By similarity). SEQUENCE SIMILARITIES: Belongs to the splicing factor SR family.Contains 2 RRM (RNA recognition motif) domains. View All» Product Name: Anti-SRp55 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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