货号：06-1332

品牌：Merck Millipore

规格：EA

目录价：￥4164.00

市场价格：￥3539.40

会员价格：￥3331.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Leo1 Antibody | 06-1332 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Leo1. View All» Molecular Weight: ~110 kDa View All» Immunogen: GST-tagged recombinant protein corresponding to human Leo1. View All» Background Information: Leo1, which is highly expressed in the nucleus of both skeletal muscle and heart tissues, as well in the placenta and liver, is one of four subunits that make up the PAF1/RNA polymerase II transcription. The PAF1/RNA polymerase II transcription complex has been shown to aid in the regulation of transcriptional elongation, histone methylation, and RNA processing. Deletion of Leo1 by itself leads to few obvious phenotypes. However, in combination with a PAF1 deletion, the additional deletion of the Leo1 protein suppresses several phenotypes which result from the defective PAF1 complex and a block in transcription. Conversely, when the Leo1 protein is overexpressed, it has also been shown to induce arrest of cell growth and the premature senescence of fibroblasts. View All» Species Reactivity: Human View All» Species Reactivity Note: Proven to react with human. Mouse (92% sequence homology). Rat (93% sequence homology). View All» Application Notes: Western Blot (SNAP ID) Analysis: A 1:500 dilution from a previous lot detected Leo1 in Jurkat cell lysate. Immunocytochemistry Analysis: A 1:500 dilution from a previous lot detected Leo1 in HeLa, A431, and Huvec lysates. View All» Control: Jurkat cell lysate View All» Quality Assurance: Evaluated by Western Blot in Jurkat cell lysate.Western Blot Analysis: A 1:1000 dilution of this antibody detected Leo1 on 10 µg of Jurkat cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal containing 0.1 M Tris-Glycine, pH 7.4, 0.150 mM NaCl and 0.05% Sodium Azide. View All» UniProt Number: Q8WVC0 View All» Entrez Gene Number: NP_620147.1 View All» Gene Symbol: RDL View All» Alternate Names:

• Leo1, Paf1/RNA polymerase II complex component, homolog

• Leo1, Paf1/RNA polymerase II complex component, homolog (S.cerevisiae)

• Replicative senescence down-regulated leo1-like protein

• replicative senescence downregulated leo1-like

• senescence downregulated leo1-like
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunocytochemistry
    View All» Entrez Gene Summary: LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]). View All» UniProt Summary: FUNCTION: The PAF1 complex is a multifunctional complex. The PAF1 complex interacts with POLR2A. May be involved in both initiation and elongation, histone methylation and RNA processing. Overexpression of LEO1 induces cell growth arrest and premature senescence of fibroblasts. SUBUNIT STRUCTURE: Component of the PAF1 complex, which consists of at least of CDC73, PAF1, LEO1 and CTR9. Interacts with CDC73. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Highly expressed in skeletal muscle and heart. Weakly expressed in placenta and liver. SEQUENCE SIMILARITIES: Belongs to the LEO1 family. View All» Product Name: Anti-Leo1 Antibody (06-1332) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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