货号：06-133

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Fyn Antibody | 06-133 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Fyn View All» Molecular Weight: 59kDa View All» Immunogen: Synthetic peptide corresponding to aa 35-51 (TPQHYPSFGVTSIPNYN) of human Fyn View All» Isotype: IgG View All» Species Reactivity:

• Avian

• Human

• Mouse

• Rat
  View All» Quality Assurance: routinely evaluated by immunoblot on Jurkat cell lysate View All» Purification Method: Antiserum View All» Presentation: antiserum View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P06241 View All» Entrez Gene Number: NM_002037 View All» Gene Symbol:
  • FYN

  • SLK

  • MGC45350

  • SYN

  • p59-Fyn
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. View All» UniProt Summary: FUNCTION: SwissProt: P06241 # Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC.COFACTOR: Manganese.SIZE: 537 amino acids; 60762 Da SUBUNIT: Associates through its SH3 domain, to the p85 subunit of phosphatidylinositol 3-kinase. Interacts with the FYN-binding protein (FYB). Interacts with phosphorylated TOM1L1. Interacts with CD79A upon activation of the B-cell antigen receptor which increases FYN activity (By similarity). Interacts with PAG1.SUBCELLULAR LOCATION: Cell membrane. Note=Present and active in lipid rafts. Present in cell body and along the process of mature and developing oligodendroyctes.TISSUE SPECIFICITY: Isoform 1 is highly expressed in the brain, isoform 2 is expressed in cells of hemopoietic lineages, especially T lymphocytes.SIMILARITY: SwissProt: P06241 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain. View All» Brand Family: Upstate View All» Product Name: Anti-Fyn Antibody | 06-133 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 250 µL View All» Format: Serum View All» Host: Rabbit View All»
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