货号：06-1293

品牌：Merck Millipore

规格：EA

目录价：￥3348.00

市场价格：￥2845.80

会员价格：￥2678.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-hCMT1 Antibody | 06-1293 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes hCMT1. View All» Molecular Weight: ~55 kDa View All» Immunogen: His-tagged recombinant protein corresponding to full length hCMT1. View All» Background Information: hCMT1 or mRNA (guanine-N(7)-)-methyltransferase belongs to the mRNA cap methyltransferase family. It is widely expressed across various tissues and is located in the nucleus. hCMT1 fuctions as a mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. It also binds RNA containing 5'-terminal GpppC. hCMT1 interacts with importin alpha, leading to the stimulation of both RNA-binding and methyltransferase activity. Interaction with importin alpha and beta is required for its nuclear localization. Importin beta dissociating in response to RanGTP allows RNMT-importin alpha to bind RNA substrates. hCMT1 also interacts with elongating form of polymerase II and RNGTT. View All» Species Reactivity: Human View All» Species Reactivity Note: Proven to react with human. Mouse and rat (77% sequence homology). View All» Application Notes: Western Blot Analysis: A 1:1,000 dilution from a previous lot detected hCMT1 in 10 µg of HeLa cell lysate. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: A 1:1,000 dilution of this antibody detected hCMT1 in 10 µg of HeLa cell lysate. View All» Purification Method: Unpurified View All» Presentation: Sheep polyclonal serum containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: O43148 View All» Entrez Gene Number: NP_003790.1 View All» Gene Symbol:

• DKFZp686H1252

• EC 2.1.1.56

• KIAA0398

• MET

• OTTHUMP00000162509

• RG7MT1

• hCMT1

• hCMT1c

• hMet

• hcm1p
  View All» Alternate Names:
  • RNA (guanine-7-) methyltransferase

  • mRNA (guanine-7-)methyltransferase

  • mRNA (guanine-N(7)-)-methyltransferase

  • mRNA cap methyltransferase
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNTION: mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC. CATALYTIC ACTIVITY: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA.SUBUNIT STRUCTURE: Interacts with importin alpha, leading to stimulate both RNA-binding and methyltransferase activity. Interaction with importin alpha and beta is required for its nuclear localization, importin beta dissociating in response to RanGTP, allowing RNMT-importin alpha to bind RNA substrates. Interacts with elongating form of polymerase II and RNGTT. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Widely expressed. SEQUENCE SIMILARITIES: Belongs to the mRNA cap methyltransferase family. View All» Product Name: Anti-hCMT1 Antibody (06-1293) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Sheep View All»
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