货号：06-1104

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-P/CAF Antibody | 06-1104 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the internal domain of P/CAF. View All» Molecular Weight: ~ 93 kDa View All» Epitope: Internal View All» Immunogen: KLH-conjugated linear peptide corresponding to the internal domain of human P/CAF. View All» Background Information: P/CAF(sometimes called KAT2B) is a transcription cofactor with a histone acetyltransferase (HAT) activity. Consistent with this protein playing a direct role in transcriptional regulation, P/CAF can acetylate core histones H3 and H4, chromatin proteins HMG17 and HMG I(Y), as well as human immunodeficiency virus Tat, transcription factor MyoD, and general transcription factors TFIIE and TFIIF. A role for P/CAF in cell growth and differentiation is suggested by its interaction in vivo and in vitro with p300/CBP, two large nuclear proteins that bind to sequence-specific factors involved in cell growth/differentiation. A role for P/CAF in cell division is also suggested by data showing that this protein competes with E1A for binding sites in p300/CBP to counteract E1A's mitogenic activity. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Chimpanzee
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. Predicted to react with chimpanzee and rhesus monkey based on 100% sequence homology. View All» Application Notes: Western Blot (SNAP ID) Analysis: 1 µg/ml from a representative lot detected P/CAF on 10 µg of A431 cell lysate. View All» Control: A431 cell lysate View All» Quality Assurance: Evaluated by Western Blot in A431 cell lysate.Western Blot Analysis: 0.5 µg/ml of this antibody detected P/CAF on 10 µg of A431 cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q92831 View All» Entrez Gene Number: NP_003875 View All» Gene Symbol:
  • KAT2B

  • CAF

  • GCN5

  • GCN5L

  • P

  • P/CAF

  • PCAF
    View All» Alternate Names:
    • CREBBP-associated factor

    • Histone acetylase PCAF

    • K(lysine) acetyltransferase 2B

    • P300/CBP-associated factor

    • Histone acetyltransferase KAT2B
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. CATALYTIC ACTIVITY: Acetyl-CoA + histone = CoA + acetylhistone. SUBUNIT STRUCTURE: Interacts with SIRT1 By similarity. Interacts with EP300 and CREBBP. Interacts with NCOA1 and NCOA3. Component of a large chromatin remodeling complex, at least composed of MYSM1, KAT2B/PCAF, RBM10 and KIF11/TRIP5. Binds to HTLV-1 Tax. Interacts with and acetylates HIV-1 Tat. Interacts with KLF1; the interaction does not acetylate KLF1 and there is no enhancement of its transactivational activity. Interacts with NFE4. SUBCELLULAR LOCATION: Nucleus By similarity UniProtKB Q92830. TISSUE SPECIFICITY: Ubiquitously expressed but most abundant in heart and skeletal muscle. DOMAIN: The bromodomain mediates binding to HIV-1 Tat.SEQUENCE SIMILARITIES: Belongs to the GCN5 family.Contains 1 bromo domain.Contains 1 N-acetyltransferase domain. View All» Product Name: Anti-P/CAF View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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