货号：06-1079

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Interleukin 23 alpha (IL-23A) Antibody | 06-1079 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Antibody recognizes the mature chain of IL-23 subunit alpha. View All» Molecular Weight: UniProtKB/Swiss-Prot entry Q9NPF7 lists a molecular weight of 20.730 kDa. In some lysates tested, non-specific bands are observed at around 40 kDa and around 55 kDa. View All» Epitope: Mature chain of IL-23, subunit alpha. View All» Immunogen: KLH-conjugated linear peptide corresponding to the mature chain of human IL-23 subunit alpha. View All» Background Information: Interleukin-23 subunit alpha (IL-23A or IL-23, p19 subunit) is a subunit of heterodimeric cytokine IL-23, which also contains the p40 subunit of interleukin 12 (IL-12B). The receptor of IL-23 is formed by the beta 1 subunit of IL-12 (IL-12RB1) and an IL-23 specific subunit, IL-23R. IL-23 activates the transcription activator STAT4, and stimulates the production of interferon-gamma. IL-23 is an important part of the inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration. Recently, IL-23 has been implicated in the development of cancerous tumors. In conjunction with IL-6 and TGF-β1, IL-23 stimulates naive CD4+ T cells to differentiate into a novel subset of cells called Th17 cells, which are distinct from the classical Th1 and Th2 cells. Th17 cells produce IL-17, a proinflammatory cytokine that enhances T cell priming and stimulates the production of proinflammatory molecules such as IL-1, IL-6, TNF-alpha, NOS-2, and chemokines resulting in inflammation. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. Predicted to react with rhesus monkey based on 100% sequence homology. View All» Application Notes: Flow Cytometry Analysis: 1 µg from a previous lot detected IL-23 alpha in human PBMC's. View All» Control: 3T3/A31 cell lysate View All» Quality Assurance: Evaluated by Western Blot in 3T3/A31 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected IL-23 alpha in 10 µg of 3T3/A31 cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in PBS with 0.09% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9NPF7 View All» Entrez Gene Number: NP_057668 View All» Gene Symbol:
  • IL23A

  • IL-23

  • IL-23A

  • IL-23p19

  • IL23P19

  • P19

  • SGRF
    View All» Alternate Names:
    • IL-23 subunit alpha

    • Interleukin-23 subunit p19

    • JKA3 induced upon T-cell activation

    • interleukin 23 p19 subunit

    • interleukin 23, alpha subunit p19
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Flow Cytometry
        View All» Entrez Gene Summary: This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. SUBUNIT STRUCTURE: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23. SUBCELLULAR LOCATION: Secreted. Note: Secreted upon association with IL12B. TISSUE SPECIFICTY: Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level). DEVELOPMENTAL STAGE: Expressed by newborns dendritic cells. INDUCTION: Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors. SEQUENCE SIMILARITIES: Belongs to the IL-6 superfamily. View All» Product Name: Anti-Interleukin 23 alpha (IL-23A) View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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