货号：06-1075

品牌：Merck Millipore

规格：

目录价：￥3323.00

市场价格：￥2824.55

会员价格：￥2658.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-IL-21 Receptor Antibody | 06-1075 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the cytoplasmic domain of IL-21 Receptor. View All» Molecular Weight: Expected molecular weight ~59 kDa. The Molecular Weight of the recombinant protein used for Western Blot is expected and observed around ~85 kDa with its N-terminal GST-tag. View All» Epitope: Cytoplasmic Domain View All» Immunogen: KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human IL-21 Receptor. View All» Background Information: Interleukin 21 receptor (IL-21R) is a type I cytokine receptor for interleukin 21 (IL-21). IL-21R forms a heterodimeric receptor complex with the common gamma-chain receptor subunit also shared by interleukin 2 receptor and interleukin 5 receptor. IL-21 receptor is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The signaling cascade of IL-21R results in the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. View All» Species Reactivity:

• Human

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human and rat. Mouse (77% sequence homology). View All» Application Notes: Western Blot Analysis: 0.1 µg/mL from a previous lot detected IL-21 Receptor on 10 µg of IL-21 Receptor recombinant protein.Immunohistochemistry Analysis: A 1:100 dilution from a previous lot detected IL-21 Receptor in rat lung tissue.Flow Cytometry Analysis: 10 µg from a previous lot detected IL-21 Receptor in K562 cells. View All» Control: K562 cell lysate, IL-21R recombinant protein View All» Quality Assurance: Evaluated by Western Blot in K562 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected IL-21 Receptor on 10 µg of K562 cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in PBS with 0.09% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9HBE5 View All» Entrez Gene Number: NP_068570 View All» Gene Symbol:
  • IL21R

  • IL-21R

  • NILR
    View All» Alternate Names:
    • Interleukin 21 receptor

    • IL-21 receptor

    • Interleukin-21 receptor
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry

      • Flow Cytometry
        View All» Entrez Gene Summary: The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: This is a receptor for interleukin-21.SUBUNIT STRUCTURE: Heterodimer with the common gamma chain. Associates with JAK1.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICTY: Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The box 1 motif is required for JAK interaction and/or activation.SEQUENCE SIMILARITIES: Belongs to the type I cytokine receptor family. Type 4 subfamily.Contains 1 fibronectin type-III domain. View All» Product Name: Anti-IL-21 Receptor View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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