货号：06-1071

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Interleukin 17 Receptor Beta (IL-17RB) Antibody | 06-1071 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the extracellular domain of IL-17 receptor B. View All» Molecular Weight: UniProtKB/Swiss-Prot entry Q9JIP3 (I17RB_MOUSE) describes 2 isoforms produced by alternative splicing: isoform 1 at ~56 kDa, isoform 2 at ~24 kDa. View All» Epitope: Extracellular domain View All» Immunogen: KLH-conjugated linear peptide corresponding to the extracellular domain of human IL-17 receptor B. View All» Background Information: Interleukin-17 receptor B (IL-17RB) is a cytokine receptor that specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. IL-17 is a proinflammatory cytokine produced by activated T cells and regulates the activities of NF-kappaB and mitogen-activated protein kinases. High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. IL-17RB has been shown to mediate the activation of NF-kappaB and the production of IL-8 induced by IL17E (IL-25). Overexpression of IL-17RB is linked to nonrecurrence after tamoxifen chemoprophylaxis in hormone receptor-positive breast cancer, thus pointing out a potential involvement of its known ligands, IL-17B and IL-17E respectively. View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. No sequence homology to rat. View All» Application Notes: Flow Cytometry Analysis: 1 µg from a previous lot detected IL-17 receptor B in human PBMC's. View All» Control: Mouse testis lysate View All» Quality Assurance: Evaluated by Western Blot in mouse testis lysate.Western Blot Analysis: 1 µg/mL of this antibody detected IL-17 receptor B on 10 µg of mouse testis lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9JIP3 View All» Entrez Gene Number: NP_062529 View All» Gene Symbol:
  • IL17RB1/27/201

  • CRL4

  • EVI27

  • IL-17RB

  • IL-17Rh1

  • IL17BR

  • IL17RH1

  • IL17Rh1
    View All» Alternate Names:
    • Cytokine receptor CRL4

    • IL-17 receptor B

    • IL-17 receptor homolog 1

    • IL-17B receptor

    • Interleukin-17B receptor

    • interleukin 17 receptor B

    • interleukin 17 receptor homolog 1

    • interleukin 17B receptor
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Flow Cytometry
        View All» UniProt Summary: FUNCTION: Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. TISSUE SPECIFICTY: Liver and testis. Expressed at lower level in kidney and lung. Expressed in selected T-cell, B-cell and myeloid cell lines.MISCELLANEOUS: Evi27 is a common site of retroviral integration in Bxh2 murine myeloid leukemias, localized near the Il17rb gene. Proviral integrations result in increased expression of Il17rb on the cell surface. View All» Product Name: Anti-Interleukin 17 Receptor Beta (IL-17RB) View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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