货号：06-1062

品牌：Merck Millipore

规格：EA

目录价：￥3108.00

市场价格：￥2641.80

会员价格：￥2486.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Deubiquitinating enzyme A (DUBA) Antibody | 06-1062 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Deubiquitinating enzyme A (DUBA). View All» Molecular Weight: ~ 62 kDa View All» Epitope: Recognizes all Isoforms of Deubiquitinating enzyme A (DUBA). View All» Immunogen: KLH-conjugated linear peptide corresponding to human Deubiquitinating enzyme A (DUBA). View All» Background Information: Deubiquitinating enzyme A (DUBA), an ovarian tumor domain-containing deubiquitinating enzyme, is a negative regulator of innate immune system and a regulator of type I interferon production. DUBA's deubiquitinating activity is directed towards 'Lys-63'-linked polyubiquitin chains and can be inhibited by N-ethyl-maleimide (NEM). DUBA binds to tumor necrosis factor receptor–associated factor 3 (TRAF3), an adaptor protein essential for type I interferon response. TRAF3 is an E3 ubiquitin ligase that preferentially assembles lysine-63–linked polyubiquitin chains. DUBA selectively cleaves the lysine-63–linked polyubiquitin chains on TRAF3, resulting in its dissociation from the downstream signaling complex containing TANK-binding kinase 1. (Kayagaki, N., et al., 2007) View All» Species Reactivity:

• Human

• Mouse

• Canine

• Bovine

• Chimpanzee

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. Predicted to react with canine, bovine, chimpanzee, and rat based on 100% sequence homology. View All» Application Notes: Western Blot Analysis: 1 µg/mL from a previous lot detected Deubiquitinating enzyme A (DUBA) on 10 µg of NIH/3T3 cell lysate.Western Blot (SNAP ID) Analysis: 1 µg/mL from a previous lot detected Deubiquitinating enzyme A (DUBA) on 10 µg of Jurkat cell lysate. View All» Control: Jurkat cell lysate View All» Quality Assurance: Evaluated by Western Blot in Jurkat cell lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected Deubiquitinating enzyme A (DUBA) on 10 µg of Jurkat cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q96G74 View All» Entrez Gene Number: NP_060072 View All» Gene Symbol:
  • DUBA

  • OTUD5
    View All» Alternate Names:
    • Deubiquinating enzyme A

    • OTU domain containing 5
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Negative regulator of innate immune system. Has deubiquitinating activity that is directed towards 'Lys-63'-linked polyubiquitin chains. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. CATALYTIC ACTIVITY: Ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.ENZYME REGULATION: Inhibited by N-ethyl-maleimide (NEM).SUBUNIUT STRUCTURE: Interacts with TRAF3.TISSUE SPECIFICITY: Expressed in various tissues, including the liver and placenta, as well as in peripheral blood leukocytes. INDUCTION: By bacterial lipopolysaccharides (LPS) in bone marrow-derived macrophages.SEQUENCE SIMILARTIES: Belongs to the peptidase C85 family.Contains 1 OTU domain. View All» Product Name: Anti-Deubiquitinating enzyme A (DUBA) View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://16ao.com/thread-134221.htm
      © Merck Millipore代理06-1062 Anti-Deubiquitinating enzyme A (DUBA)，产品报价联系微信jinshanbio