货号：06-1061

品牌：Merck Millipore

规格：EA

目录价：￥3108.00

市场价格：￥2641.80

会员价格：￥2486.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CARD11 Antibody | 06-1061 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the internal domain of CARD11. View All» Molecular Weight: ~133 kDa.A non-specific band may be observed at ~51 kDa and >260kDa. View All» Epitope: Internal Domain View All» Immunogen: KLH-conjugated linear peptide corresponding to the internal domain of human CARD11. View All» Background Information: CARD11 is part of a group of CARD containing proteins, or proteins that contain caspase recruitment domain, belonging to the membrane-associated guanylate kinase (MAGUK) family functioning as molecular scaffolds at specialized locations of the plasma membrane for the production of multiprotein complexes. The CARD domain is a module for protein-binding that helps to regulate the production of CARD-containing proteins into complexes that signal NF-κB. CARD11 is a multidomain adaptor that is necessary for T-cell receptor (TCR) signaling activation of NF-κB as a necessary component of T-cell activation during adaptive immune response. In this pathway, CARD11 undergoes phosphorylation between its PDZ and coiled-coil domains by protein kinase D (PKC) on serine residues 564, 577, and 657 in order to activate NF-κB. Along with immunity, NF-κB is a critical component in the gene activation for pathways such as inflammation and apoptosis. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Horse

• Canine
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with mouse, rat, equine, and canine based on 100% sequence homology. Bovine (95% sequence homology). Chicken (86% sequence homology). View All» Application Notes: Western Blot (SNAP ID) Analysis: 0.25 µg/mL of this antibody detected CARD11 in 10 µg of Daudi cell lysate. View All» Control: Daudi cell lysate View All» Quality Assurance: Evaluated by Western Blot in Daudi cell lysate.Western Blot Analysis: 0.25 µg/mL of this antibody detected CARD11 in 10 µg of Daudi cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9BXL7 View All» Entrez Gene Number: NP_115791 View All» Gene Symbol:
  • CARMA1

  • CARD11

  • BIMP3
    View All» Alternate Names:
    • caspase recruitment domain family, member 11

    • card-maguk protein 1

    • Carma 1

    • bcl10-interacting maguk protein 3

    • CARD-containing MAGUK protein 3
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.SUBUNIT STRUCTURE: Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. CARD11 and BCL10 bind to each other by CARD-CARD interaction. Interacts (via PDZ domain) with DPP4 (via cytoplasmic tail).SUBCELLULAR LOCATION: Cytoplasm. Membrane raft. Note: Colocalized with DPP4 in membrane rafts.TISSUE SPECIFICITY: Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLa S3, Molt-4, A549 and G431 cells.SEQUENCE SIMILARITIES: Contains 1 CARD domain.Contains 1 guanylate kinase-like domain.Contains 1 PDZ (DHR) domain.CAUTION: Supposed to contain a SH3 domain which is not detected by PROSITE, Pfam or SMART.SEQUENCE CAUTION: The sequence AAQ96893.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence EAL23962.1 differs from that shown. Reason: Erroneous gene model prediction. View All» Product Name: Anti-CARD11 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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